消化道癌症中的长链非编码RNA：功能、机制及潜在生物标志物
Long Noncoding RNA in Digestive Tract Cancers: Function, Mechanism, and Potential Biomarker.
作者信息
Zeng Shuo, Xiao Yu-Feng, Tang Bo, Hu Chang-Jiang, Xie Rei, Yang Shi-Ming, Li Bo-Sheng
机构信息
Department of Gastroenterology, Xinqiao Hospital, Third Military Medical University, Chongqing, People's Republic of China.
Department of Gastroenterology, Xinqiao Hospital, Third Military Medical University, Chongqing, People's Republic of China
出版信息
Oncologist. 2015 Aug;20(8):898-906. doi: 10.1634/theoncologist.2014-0475. Epub 2015 Jul 8.
Abstract
Digestive tract cancers (DTCs) are a leading cause of cancer-related death worldwide. Current therapeutic tools for advanced stage DTCs have limitations, and patients with early stage DTCs frequently have a missed diagnosis due to shortage of efficient biomarkers. Consequently, it is necessary to develop novel biomarkers for early diagnosis and novel therapeutic targets for treatment of DTCs. In recent years, long noncoding RNAs (lncRNAs), a class of noncoding RNAs with >200 nucleotides, have been shown to be aberrantly expressed in DTCs and to have an important role in DTC development: the expression profiles of lncRNAs strongly correlated with poor survival of patients with DTCs, and lncRNAs acted as oncogenes or tumor suppressor genes in DTC progression. In this review, we summarized the functional lncRNAs and expounded on their regulatory mechanisms in DTCs.
摘要
消化道癌症（DTCs）是全球癌症相关死亡的主要原因。目前针对晚期DTCs的治疗手段存在局限性，而早期DTCs患者常因缺乏有效的生物标志物而漏诊。因此，有必要开发用于DTCs早期诊断的新型生物标志物和用于治疗DTCs的新型治疗靶点。近年来，长链非编码RNA（lncRNAs），一类长度超过200个核苷酸的非编码RNA，已被证明在DTCs中异常表达，并在DTCs的发展中起重要作用：lncRNAs的表达谱与DTCs患者的不良生存密切相关，并且lncRNAs在DTCs进展中充当癌基因或肿瘤抑制基因。在这篇综述中，我们总结了功能性lncRNAs，并阐述了它们在DTCs中的调控机制。
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