Department of Orthopaedic Surgery, Biomedical Research Institute, School of Medicine, Pusan National University Hospital, Pusan National University, 179 Gudeok-Ro, Seo-Gu, Busan, 49241, Republic of Korea.
BMC Musculoskelet Disord. 2023 Aug 29;24(1):689. doi: 10.1186/s12891-023-06793-0.
The aim of this study was to compare serum vitamin D levels in girls with adolescent idiopathic scoliosis (AIS) and controls using meta-analysis methods. We searched Medline (via PubMed), Cochrane, Scopus, and Embase databases for studies evaluating outcomes in AIS, including patient age, body mass index, bone mineral density (BMD), and serum levels of parathyroid hormone (PTH), calcium, and phosphate, published between January 2000 and June 2020. We searched for studies that were limited to humans only. The inclusion criteria were a scoliosis study that measured vitamin D levels. We excluded duplicate publications such as review articles, case reports, and letters without original data. Two authors extracted data independently and resolved any discrepancies by consensus.
Eight comparative studies were identified. Demographic characteristics, bone density, serum levels of vitamin D, parathyroid hormone, and phosphate levels were not significantly different between AIS group and controls, except for serum calcium levels. The serum calcium levels were lower in AIS group than in the controls.
This review includes eight comparative studies reporting serum vitamin D and/or parathyroid hormone levels in AIS. Due to heterogeneity, a limited number of meta-analyses have shown a weak correlation between serum vitamin D levels and the incidence of AIS. Larger, multicenter studies are therefore needed to validate the results.
本研究旨在通过荟萃分析方法比较青少年特发性脊柱侧凸（AIS）患者与对照组的血清维生素 D 水平。我们检索了 Medline（通过 PubMed）、Cochrane、Scopus 和 Embase 数据库，以评估 AIS 患者的年龄、体重指数、骨密度（BMD）以及甲状旁腺激素（PTH）、钙和磷的血清水平等结局的研究，检索时间为 2000 年 1 月至 2020 年 6 月。我们仅检索了针对人类的研究。纳入标准为测量维生素 D 水平的脊柱侧凸研究。我们排除了重复发表的文献，如综述文章、病例报告和没有原始数据的信件。两位作者独立提取数据，并通过共识解决任何分歧。
确定了 8 项比较研究。除血清钙水平外，AIS 组与对照组在人口统计学特征、骨密度、血清维生素 D、甲状旁腺激素和磷水平方面无显著差异。AIS 组的血清钙水平低于对照组。
本综述包括 8 项比较研究报告了 AIS 患者的血清维生素 D 和/或甲状旁腺激素水平。由于存在异质性，少数荟萃分析表明血清维生素 D 水平与 AIS 发生率之间存在弱相关性。因此，需要更大规模的多中心研究来验证结果。
