用于肝损伤中羧酸酯酶快速成像的近红外荧光光声探针的设计。
Design of a near-infrared fluoro-photoacoustic probe for rapid imaging of carboxylesterase in liver injury.
机构信息
Molecular Science and Biomedicine Laboratory, State Key Laboratory of Chemo/Biosensing and Chemometrics, College of Chemistry and Chemical Engineering, Hunan University, Changsha, Hunan 410082, China.
College of Chemistry & Chemical Engineering, Central South University, Changsha 410083, Hunan Province, China.
出版信息
Chem Commun (Camb). 2023 Aug 29;59(70):10520-10523. doi: 10.1039/d3cc03170e.
Carboxylesterase (CE) is crucial in metabolizing ester-containing biomolecules and is particularly significant in liver metabolic diseases. Herein, we present the first activatable NIRF/PA dual-mode imaging probe QHD-CE for detection of CE and . QHD-CE displays excellent sensitivity and selectivity for CE with a high reaction efficiency (∼90 min). By utilizing QHD-CE, the dynamic changes of CE in drug-induced liver injury and diabetic mice models were monitored.
羧酸酯酶（CE）在代谢含酯生物分子中起着至关重要的作用，在肝脏代谢疾病中尤为重要。在此，我们提出了首个可激活的近红外荧光/光声双模式成像探针 QHD-CE，用于检测 CE 和 。QHD-CE 对 CE 具有出色的灵敏度和选择性，反应效率高（约 90 分钟）。利用 QHD-CE，我们监测了药物性肝损伤和糖尿病小鼠模型中 CE 的动态变化。
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