Pan Jia, Yang Bo, Wang Zihang, Tang Lei, Jia Peng, Yang Shujuan, Zeng Honglian
Department of Clinical Medical College & Affiliated Hospital of Chengdu University, Chengdu University, Chengdu, Sichuan, People's Republic of China.
Department of West China School of Public Health and West China Fourth Hospital, Sichuan University, Chengdu, Sichuan, People's Republic of China.
Diabetes Metab Syndr Obes. 2023 Aug 24;16:2561-2571. doi: 10.2147/DMSO.S418358. eCollection 2023.
China has the highest rail transportation density in the world. Compared to other occupational populations, railway workers in China face increased risk of chronic non-communicable diseases. This study aims to investigate the relationship between the triglyceride-glucose (TyG) index and carotid artery plaque (CAP) in a population of railway workers in southwest China.
The cross-sectional study was conducted among 3169 railway workers who were categorized into four groups based on TyG index quartiles. The presence of CAP was assessed using carotid Doppler ultrasound. Logistic regression and restricted cubic spline analyses were used to estimate the association between TyG index and CAP, and subgroup analyses were performed based on age, blood pressure, metabolic dysfunction-associated fatty liver disease (MAFLD), smoking, drinking, and physical activity.
Participants with higher TyG index quartiles had a higher prevalence of CAP, with 11.63%, 14.11%, 20.20%, and 18.56% from the first to fourth quartile, respectively. The multi-adjusted logistic regression models showed a positive association between TyG index and the risk of CAP (odds ratio [OR]: 1.22, 95% confidence interval [CI]: 1.06-1.41) when treated as a continuous variable. When analyzed as a categorical variable with increasing TyG index tertiles, the risk of CAP substantially increased with ORs (95% CIs) of 1.22 (0.90-1.65) for the second quartile, 1.70 (1.27-2.28) for the third quartile, and 1.46 (1.08-1.98) for the fourth quartile compared to the lowest quartile. Restricted cubic spline revealed that the association gradually strengthened with the increase of the TyG index below 9.56.
TyG index was significantly associated with CAP, notably in populations with elevated quartiles of TyG index among railway workers. Monitoring the TyG index could be a useful risk management strategy for CAP in occupation population.
中国拥有世界上最高的铁路运输密度。与其他职业人群相比，中国铁路工人面临慢性非传染性疾病风险增加的情况。本研究旨在调查中国西南部铁路工人群体中甘油三酯 - 葡萄糖（TyG）指数与颈动脉斑块（CAP）之间的关系。
对3169名铁路工人进行横断面研究，根据TyG指数四分位数将他们分为四组。使用颈动脉多普勒超声评估CAP的存在情况。采用逻辑回归和受限立方样条分析来估计TyG指数与CAP之间的关联，并根据年龄、血压、代谢功能障碍相关脂肪性肝病（MAFLD）、吸烟、饮酒和身体活动进行亚组分析。
TyG指数四分位数较高的参与者CAP患病率较高，第一至第四四分位数分别为11.63%、14.11%、20.20%和18.56%。多因素调整逻辑回归模型显示，当TyG指数作为连续变量时，其与CAP风险呈正相关（优势比[OR]：1.22，95%置信区间[CI]：1.06 - 1.41）。当将TyG指数作为分类变量，按三分位数增加进行分析时，与最低四分位数相比，第二四分位数的CAP风险大幅增加，OR（95%CI）为1.22（0.90 - 1.65），第三四分位数为1.70（1.27 - 2.28），第四四分位数为1.46（1.08 - 1.98）。受限立方样条显示，在TyG指数低于9.56时，该关联随TyG指数的增加而逐渐增强。
TyG指数与CAP显著相关，特别是在铁路工人中TyG指数四分位数升高的人群中。监测TyG指数可能是职业人群中CAP的一种有用风险管理策略。
