Saraf-Bank Sahar, Ahmadi Alireza, Paknahad Zamzam, Maracy Mohammadreza, Nourian Mojgan
MSc. Doctoral Student and Dietitian, Students' Research Committee, Isfahan University of Medical Sciences; Doctoral Student and Dietitian, Food Security Research Center, Isfahan University of Medical Sciences; and Doctoral Student and Dietitian, Department of Community Nutrition, School of Nutrition and Food Science, Isfahan University of Medical Sciences, Isfahan, Iran.
MD. Associate Professor and Cardiologist, Pediatric Cardiovascular Research Center, Cardiovascular Research Institute, Isfahan University of Medical Sciences, Isfahan, Iran.
Sao Paulo Med J. 2019 Sep-Oct;137(5):414-422. doi: 10.1590/1516-3180.2018.0454120419.
BACKGROUND: Obese adolescents are at higher risk of development of cardiovascular risk factors and obesity in later life. Dietary intake of antioxidants, particularly curcumin, as an active ingredient of turmeric extract, may have noticeable effects on obesity and its important complications such as cardiovascular risk factors. Therefore, the aim of this study was to assess the effects of curcumin supplementation on cardiovascular risk factors among overweight and obese female adolescents. DESIGN AND SETTING: Randomized placebo-controlled clinical trial; Pediatric Cardiovascular Research Center, Isfahan, Iran. METHODS: 60 adolescent girls (aged 13-18 years) were randomly assigned to receive either placebo or intervention. The adolescents were asked to consume one 500 mg tablet per day, containing either standardized 95% turmeric extract or placebo, and to undergo a weight maintenance or a mild weight loss diet for 10 weeks. Anthropometric and biochemical indices were assessed at the baseline and the end of the intervention. RESULTS: Curcumin supplementation had beneficial effects on body mass index (P = 0.019), waist circumference (P = 0.008), hip circumference (P = 0.030), high-density lipoprotein levels (P = 0.042) and triglyceride/high-density lipoprotein ratio (P = 0.021). However, in univariate analysis of covariance, no significant differences were found between the intervention and placebo groups after 10 weeks of supplementation (P > 0.05). CONCLUSIONS: Prescription of curcumin supplementation along with use of a slight weight loss diet might have beneficial effects on some cardiovascular risk factors among overweight and obese female adolescents. Larger clinical trials with higher curcumin doses and longer duration are needed to confirm the results from the current study. CLINICAL TRIAL REGISTRATION: IRCT20171107037302N1.
背景：肥胖青少年在日后生活中发生心血管危险因素及肥胖的风险更高。抗氧化剂的饮食摄入，尤其是姜黄素，作为姜黄提取物的活性成分，可能对肥胖及其重要并发症如心血管危险因素有显著影响。因此，本研究的目的是评估补充姜黄素对超重和肥胖女性青少年心血管危险因素的影响。 设计与地点：随机安慰剂对照临床试验；伊朗伊斯法罕儿科心血管研究中心。 方法：60名年龄在13 - 18岁的青春期女孩被随机分配接受安慰剂或干预。要求青少年每天服用一片500毫克的片剂，其中包含标准化的95%姜黄提取物或安慰剂，并进行体重维持或轻度减重饮食10周。在基线和干预结束时评估人体测量和生化指标。 结果：补充姜黄素对体重指数（P = 0.019）、腰围（P = 0.008）、臀围（P = 0.030）、高密度脂蛋白水平（P = 0.042）和甘油三酯/高密度脂蛋白比值（P = 0.021）有有益影响。然而，在协方差单因素分析中，补充10周后干预组和安慰剂组之间未发现显著差异（P > 0.05）。 结论：补充姜黄素并结合轻度减重饮食可能对超重和肥胖女性青少年的一些心血管危险因素有有益影响。需要更大规模、更高姜黄素剂量和更长疗程的临床试验来证实本研究结果。 临床试验注册：IRCT20171107037302N1。
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