Ziegler W
Strahlenther Onkol. 1986 Aug;162(8):514-8.
During a combined treatment of human melanoma cells with Cisplatin and irradiation under aerobic conditions, interaction between the two treatment modalities is observed. The presence of Cisplatin during irradiation leads to an increased bending, pretreatment with Cisplatin to an increased initial steepness of the survival curve irrespective of the time interval and the Cisplatin dose. Post-treatment with Cisplatin, however, does not influence the shape of the survival curve. Simultaneous treatment of human melanoma cells with Cisplatin and irradiation in hypoxia does not result in the radiosensitization seen under aerobic conditions.
在有氧条件下用顺铂和辐射联合处理人黑色素瘤细胞时，可观察到两种处理方式之间的相互作用。辐射期间顺铂的存在会导致弯曲增加，无论时间间隔和顺铂剂量如何，用顺铂预处理会导致存活曲线的初始斜率增加。然而，顺铂后处理并不影响存活曲线的形状。在缺氧条件下用顺铂和辐射同时处理人黑色素瘤细胞不会导致在有氧条件下观察到的放射增敏作用。
