[Effect of combined treatment with cisplatin and irradiation on the survival of human melanoma cells].

During a combined treatment of human melanoma cells with Cisplatin and irradiation under aerobic conditions, interaction between the two treatment modalities is observed. The presence of Cisplatin during irradiation leads to an increased bending, pretreatment with Cisplatin to an increased initial steepness of the survival curve irrespective of the time interval and the Cisplatin dose. Post-treatment with Cisplatin, however, does not influence the shape of the survival curve. Simultaneous treatment of human melanoma cells with Cisplatin and irradiation in hypoxia does not result in the radiosensitization seen under aerobic conditions.