State Key Laboratory of Southwestern Chinese Medicine Resources, school of pharmacy, Chengdu University of Traditional Chinese Medicine, 1166 Liutai Avenue, Wenjiang District, Chengdu, Sichuan, China.
State Key Laboratory of Southwestern Chinese Medicine Resources, school of pharmacy, Chengdu University of Traditional Chinese Medicine, 1166 Liutai Avenue, Wenjiang District, Chengdu, Sichuan, China.
Phytomedicine. 2023 Nov;120:155022. doi: 10.1016/j.phymed.2023.155022. Epub 2023 Aug 14.
Traditional Chinese Medicine (TCM) system is a medical system that has been expanding for thousands of years that was formed by the extensive clinical practice experience of many physicians and the accumulation of personal medication habits in China. In TCM, there is a history of long-term medication for epilepsy, the main treatment for epilepsy is TCM drugs and its prescription, supplemented by TCM modalities such as acupuncture therapy, moxibustion therapy, tuina, emotion adjustment therapy, etc. PURPOSE: With the modernization of TCM, the active ingredients and molecular mechanisms of TCM for epilepsy treatment have been gradually revealed. This review aimed to comprehensively summarize the TCM treatment of epilepsy, focusing on the current TCM drugs and some TCM formulae for the treatment of epilepsy, and to discuss the research progress of TCM for the treatment of epilepsy, and to provide a reference to develop future related studies in this field.
The mechanism of action of antiepileptic drugs (AEDs) was interpreted from different perspectives by searching online databases and querying various materials identify drugs used in both modern medicine and TCM systems for the treatment of epilepsy. We collected all relevant TCM for epilepsy literature published in the last 30 years up to December 2022 from electronic databases such as PubMed, CNKI and Web of Science, and statistically analyzed the literature for the following keyword information. The search terms comprise the keywords "TCM", "phytochemistry", "pharmacological activity", "epilepsy" and "traditional application" as a combination. Scientific plant names were provided by "The Plant List" (www.theplantlist.org).
Epilepsy is a complex and serious disease of the brain and nervous system. At present, the treatment of epilepsy in modern medicine is mainly surgery and chemotherapy, but there are many serious side effects. By summarizing the treatment of epilepsy in TCM, it is found that there are various methods to treat epilepsy in TCM, mainly TCM drugs and its formulae. Many TCM drugs have antiepileptic effects. Now found that the main effective TCM drugs for the treatment of epilepsy are Curcumae Longae Rhizoma, Scorpio, Acori Tatarinowii Rhizoma, Uncariae Ramulus Cum Uncis and Ganoderma, etc. And the main compounds that play a role in the treatment of epilepsy are curcumin, gastrodin, ligustrazine, baicalin and rhynchophylline, etc. These TCM drugs have played an important role in the treatment of epilepsy in TCM clinic. However, the chemically active components of these TCM drugs are diverse and their mechanisms of action are complex, which are not fully understood and need to be further explored.
TCM treats epilepsy in a variety of ways, and with the discovery of a variety of potential bioactive substances for treatment of epilepsy. With the new progress in the research of other TCM treatment methods for epilepsy, TCM will have greater potential in the clinical application of epilepsy.
中医药学是一种医学体系，已经有几千年的历史，是由中国众多医生的广泛临床实践经验和个人用药习惯的积累形成的。在中医药学中，癫痫的长期治疗有悠久的历史，癫痫的主要治疗方法是中医药药物及其处方，辅以针灸疗法、艾灸疗法、推拿、情志调节疗法等中医药疗法。目的：随着中医药现代化的发展，中医药治疗癫痫的有效成分和分子机制逐渐被揭示。本综述旨在全面总结中医药治疗癫痫的方法，重点介绍目前中医药治疗癫痫的药物和一些中医药方剂，并探讨中医药治疗癫痫的研究进展，为该领域未来的相关研究提供参考。
通过检索在线数据库和查询各种材料，从不同角度解读抗癫痫药物（AEDs）的作用机制，以确定现代医学和中医药系统治疗癫痫的药物。我们从 PubMed、CNKI 和 Web of Science 等电子数据库中收集了过去 30 年中所有与中医药治疗癫痫相关的文献，并对文献进行了以下关键词信息的统计分析。检索词包括“TCM”、“植物化学”、“药理活性”、“癫痫”和“传统应用”的组合。科学植物名称由“植物名录”（www.theplantlist.org）提供。
癫痫是一种复杂而严重的脑和神经系统疾病。目前，现代医学治疗癫痫主要是手术和化疗，但存在许多严重的副作用。通过总结中医药治疗癫痫的方法，发现中医药治疗癫痫的方法有多种，主要是中医药药物及其方剂。许多中医药药物具有抗癫痫作用。现已发现，治疗癫痫的主要有效中医药药物有姜黄、蝎子、石菖蒲、钩藤和灵芝等。治疗癫痫的主要化合物有姜黄素、天麻素、川芎嗪、黄芩苷和钩藤碱等。这些中医药药物在中医药临床治疗癫痫方面发挥了重要作用。然而，这些中医药药物的化学活性成分多样，作用机制复杂，尚未完全了解，需要进一步探索。
中医药治疗癫痫的方法多种多样，随着对治疗癫痫的各种潜在生物活性物质的发现。随着对其他中医药治疗癫痫方法研究的新进展，中医药在癫痫的临床应用中将具有更大的潜力。
