Department of Obstetrics and Gynecology, Institute of Mother and Child, Warsaw, Poland.
Department of Medical Genetics, Institute of Mother and Child, Warsaw, Poland.
Climacteric. 2023 Dec;26(6):601-604. doi: 10.1080/13697137.2023.2246878. Epub 2023 Aug 30.
The aim of this study is to present the case report of a 36-year-old woman developing premature ovarian insufficiency (POI) after COVID-19 and review the literature referring to the possible impact of SARS-CoV-2 infection on female reproduction.
A 36-year-old nulligravida with normal menstrual cycles, non-smoker, with a normal body mass index and no pelvic surgery or oncological treatment in her medical history presented to the Infertility Center of the Institute of Mother and Child in Warsaw after a year of unsuccessful attempts to get pregnant. During diagnostic process she was affected by COVID-19 with a mild manifestation and thereafter she presented amenorrhea with intense hot flushes. Further diagnostic confirmed the diagnosis of POI.
There is a strong molecular basis for a possible effect of SARS-CoV-2 infection on the female reproductive system; however, the results of available research are conflicting. All of these aspects are discussed in detail.
SARS-CoV-2 infection may cause serious complications that cast a long shadow on a patient's future life and health. Further research is needed to assess the real impact of SARS-CoV-2 infection on female reproductive health, as well as potential preventive and therapeutic strategies for women affected with COVID-19.
本研究旨在报告一例 COVID-19 后发生卵巢早衰（POI）的 36 岁女性病例，并回顾文献中提到的 SARS-CoV-2 感染对女性生殖可能产生的影响。
一名 36 岁的初产妇，月经周期正常，不吸烟，体重指数正常，无盆腔手术或肿瘤治疗史，因一年未孕来华沙母婴研究所不孕中心就诊。在诊断过程中，她感染了 COVID-19，表现为轻症，此后出现闭经和严重的热潮红。进一步的诊断证实了 POI 的诊断。
SARS-CoV-2 感染对女性生殖系统可能产生影响有很强的分子基础，但现有研究结果存在矛盾。详细讨论了所有这些方面。
SARS-CoV-2 感染可能导致严重并发症，对患者未来的生活和健康产生长期影响。需要进一步研究以评估 SARS-CoV-2 感染对女性生殖健康的真实影响，以及针对 COVID-19 感染女性的潜在预防和治疗策略。
