海洋来源真菌 Aspergillus sp. 中新型海兔内酯倍半萜和角鲨烷倍半萜

New ophiobolin sesterterpenoid and drimane sesquiterpenoids from a marine-alga-derived fungus Aspergillus sp.

机构信息

Yantai Institute of Coastal Zone Research, Chinese Academy of Sciences, Yantai 264003, People's Republic of China.

出版信息

Fitoterapia. 2023 Oct;170:105659. doi: 10.1016/j.fitote.2023.105659. Epub 2023 Aug 28.

DOI:10.1016/j.fitote.2023.105659

Abstract

Further investigation of secondary metabolites of a marine-alga-derived fungus Aspergillus sp. RR-YLW-12 led to isolate one new ophiobolin-type sesterterpenoid (1), four new drimane-type sesquiterpenoids (2-5) and one natural occurring compound (6), together with seven known compounds (7-13). Their structures and stereochemistry were elucidated by extensive spectroscopic analysis of NMR and HRMS experiments, and by comparison with the literature data. All isolates were evaluated for growth inhibition of five marine harmful microalgae. The new compounds exhibited significant to moderate inhibitory effects towards all tested microalgae species with IC values ranging from 5.8 to 54.5 μg/mL.

摘要

进一步研究海洋藻类来源真菌 Aspergillus sp. RR-YLW-12 的次生代谢产物，从中分离得到一个新的海兔毒素型甾体二萜（1）、四个新的角鲨烷型倍半萜（2-5）和一个天然存在的化合物（6），以及七个已知化合物（7-13）。通过对 NMR 和 HRMS 实验的广泛光谱分析以及与文献数据的比较，确定了它们的结构和立体化学。所有分离物均用于抑制五种海洋有害微藻的生长。这些新化合物对所有测试的微藻物种均显示出显著至中度的抑制作用，IC 值范围为 5.8 至 54.5μg/mL。