School of Pharmacy, Henan University of Chinese Medicine, Zhengzhou, 450046, PR China; Co-construction Collaborative Innovation Center for Chinese Medicine and Respiratory Diseases By Henan & Education Ministry of PR China, PR China; Henan Provincial Key Laboratory for Clinical Pharmacy of Traditional Chinese Medicine, The First Affiliated Hospital of Henan University of Chinese Medicine, Zhengzhou 450003, PR China.
School of Pharmacy, Henan University of Chinese Medicine, Zhengzhou, 450046, PR China; Co-construction Collaborative Innovation Center for Chinese Medicine and Respiratory Diseases By Henan & Education Ministry of PR China, PR China.
Phytochemistry. 2023 Nov;215:113840. doi: 10.1016/j.phytochem.2023.113840. Epub 2023 Aug 28.
Fifteen undescribed diterpenoid quinones salviamilthone A-O (1-15), together with three known diterpenoid quinones (16-18), were isolated from the roots of Salvia miltiorrhiza Bunge. Their structures were elucidated using 1D and 2D NMR data, while the relative and absolute configurations were confirmed by NOESY correlations and comparison between experimental and calculated ECD spectra. In the evaluation of bioactivities, salviamilthone J (10), salviamone (18) (10 μM) significantly increased cell viability and decreased the expression of IL-1β in lipopolysaccharide-induced BEAS-2B cells. These data provide the molecular justification for the usage of Salvia miltiorrhiza in treating acute lung injury.
从丹参根部分离得到 15 个未被描述的二萜醌类化合物 salviamilthone A-O（1-15），以及 3 个已知的二萜醌类化合物（16-18）。通过 1D 和 2D NMR 数据阐明了它们的结构，而相对和绝对构型则通过 NOESY 相关和实验与计算 ECD 光谱之间的比较来确定。在生物活性评估中，salviamilthone J（10）、salviamone（18）（10 μM）显著提高了脂多糖诱导的 BEAS-2B 细胞的活力，降低了 IL-1β 的表达。这些数据为丹参在治疗急性肺损伤中的应用提供了分子依据。
