Bishop C C, Powell S, Rutt D, Browse N L
Stroke. 1986 Sep-Oct;17(5):913-5. doi: 10.1161/01.str.17.5.913.
Measurement of intracranial arterial blood flow velocity is a new technique with potentially a number of very useful applications. This study validates the technique by comparing it to cerebral blood flow (CBF) measured using intravenous Xenon133 and extracranial clearance recording. We have measured the middle cerebral artery (MCA) blood flow velocity in 17 symptomatic patients with the EME TC 264 transcranial Doppler velocimeter and compared these measurements to the ipsilateral hemispheric cerebral blood flow measured with an intravenous Xenon133 technique (Novo Cerebrograph 10A). Measurements were made at rest and during hypercapnia. The absolute measurement of MCA velocity and hemispheric CBF showed a poor correlation (r = 0.424, p less than 0.01) due to wide between-patient variations at rest but the blood flow response to hypercapnia, expressed as a reactivity index, showed a good correlation (r = 0.849, p less than 0.001). Thus changes in MCA velocity reliably correlate with changes in cerebral blood flow but the absolute velocity cannot be used as an indicator of CBF.
颅内动脉血流速度的测量是一项新技术，可能有许多非常有用的应用。本研究通过将该技术与使用静脉注射氙133和颅外清除记录测量的脑血流量（CBF）进行比较，验证了该技术。我们使用EME TC 264经颅多普勒测速仪测量了17例有症状患者的大脑中动脉（MCA）血流速度，并将这些测量结果与使用静脉注射氙133技术（Novo Cerebrograph 10A）测量的同侧半球脑血流量进行比较。在静息状态和高碳酸血症期间进行测量。由于静息时患者之间存在较大差异，MCA速度和半球CBF的绝对测量显示出较差的相关性（r = 0.424，p < 0.01），但以反应性指数表示的对高碳酸血症的血流反应显示出良好的相关性（r = 0.849，p < 0.001）。因此，MCA速度的变化与脑血流量的变化可靠相关，但绝对速度不能用作CBF的指标。
