Faculty of Dentistry, Department of Oral and Maxillofacial Surgery, Gazi University, Ankara, Turkey.
Faculty of Dentistry, Department of Periodontology, Gazi University, Ankara, Turkey.
Clin Implant Dent Relat Res. 2021 Jun;23(3):329-340. doi: 10.1111/cid.12999. Epub 2021 Apr 14.
Studies have reported a positive effect on bone healing and the elimination of microorganisms placed on the titanium implants, while others have not confirmed the positive photobiomodulation therapy (PBMT) effects on bone regeneration and bone structure around the implants.
The aim of the present study was to address the following questions: Does PBMT improve implant stability and affect microbiota around dental implants in the early stage of osseointegration?
This study was designed as randomized-controlled prospective, split mouth, single-blinded clinical trial. Implants were randomly divided into two groups and implants placed in the test group were treated with Gallium-aluminum-arsenide (GaAlAs) diode laser with PBMT immediately after surgery and for 15 days (n = 47). In the control group, implants were not irradiated(n = 46). The primary stability of the implants was measured by the Resonance frequency analysis (RFA) after insertion and the secondary stability values were recorded at 30th, 60th, and 90th days after surgery as implant stability quotient (ISQ). The hand-held RFA was held perpendicular to the jaw line as indicated by the manufacturer for buccal-lingual (BL), mesial-distal (MD), and lingual-buccal (LB) measurement and different measurements were analyzed as separately.
Significantly higher magnetic RFA values were achieved on the 90th day in all measurement sides for both groups. ISQ levels in groups at baseline and the day-30, 60, and 90. ISQ readings were not statistically significant between test and control groups for each time point. A statistically significant increase in ISQ reading for BL, MD, and LB dimensions in both groups was noted from baseline to the day-90 (P < .05).
It was concluded that PBMT did not have a clinically significant effect on implant stabilization, especially in terms of ISQ values at early alveolar bone healing term. Clinical trial number is NCT04495335.
研究报告称，钛种植体上放置的光生物调节疗法（PBMT）对骨愈合和消除微生物有积极影响，而其他研究则未证实 PBMT 对骨再生和种植体周围骨结构的积极影响。
本研究旨在探讨以下问题：PBMT 是否能提高种植体稳定性并影响早期骨整合过程中种植体周围的微生物群？
本研究设计为随机对照前瞻性、分侧、单盲临床试验。将种植体随机分为两组，实验组种植体在手术后立即和 15 天内（n=47）用砷化镓-铝（GaAlAs）二极管激光进行 PBMT。对照组（n=46）种植体未照射。种植体插入后通过共振频率分析（RFA）测量初始稳定性，术后第 30、60 和 90 天记录二次稳定性值，即种植体稳定性指数（ISQ）。手持 RFA 按照制造商的指示垂直于颌线进行颊舌向（BL）、近远中向（MD）和舌侧向（LB）测量，不同的测量值分别进行分析。
两组在所有测量侧的第 90 天均获得了显著更高的磁性 RFA 值。两组在基线和第 30、60 和 90 天时的 ISQ 水平均无统计学差异。两组的 BL、MD 和 LB 维度的 ISQ 读数从基线到第 90 天均有显著增加（P<0.05）。
PBMT 对种植体稳定没有明显的临床效果，特别是在早期牙槽骨愈合期的 ISQ 值方面。临床试验注册号：NCT04495335。
