The First Clinical College of Medicine, Chongqing Medical University / The First Hospital of Chongqing Medical University, 1 Youyi Road, Yuanjiagang, Yuzhong District, Chongqing, 400010, China.
Int Urogynecol J. 2023 Dec;34(12):2849-2858. doi: 10.1007/s00192-023-05635-w. Epub 2023 Aug 31.
The aim of this review is to synthesize existing evidence on the combined effects of the vaginal microenvironment on pelvic dysfunctional diseases.
This systematic review was conducted in accordance with the PRISMA guidelines. The PubMed, Embase, Cochrane Library, Web of Science, Wanfang, and China Knowledge Network (CNKI) databases were systematically searched up to January 2023 using the following MeSH terms: "pelvic organ prolapse", "stress urinary incontinence" and "vaginal microenvironment", "microenvironment", "vaginal cleanliness", "vaginitis", "lactobacillus" and other related keywords. Study methods were limited to case-control studies or cross-sectional studies. Quality assessment was performed using the Newcastle-Ottawa scale, and meta-analysis of the included literature was performed using Review Manager 5.3.
A total of eight articles were included in this systematic review (SR) and meta-analysis (MA), which involved a total of 7298 study participants. The pooled results of this meta-analysis showed that the vaginal microenvironment (number of vaginal lactobacilli, leukorrhea cleanliness, and presence of vaginitis) were all statistically significantly associated with pelvic dysfunctional diseases in Chinese women.
This review indicates that the vaginal microenvironment has an impact on the development of PFD in Chinese women.
The protocol of this systematic review (SR) and meta-analysis (MA) has been registered in PROSPERO databases with the Registration number of CRD42023407251.
本综述旨在综合现有关于阴道微环境对盆腔功能性疾病的综合影响的证据。
本系统评价按照 PRISMA 指南进行。系统检索了 PubMed、Embase、Cochrane 图书馆、Web of Science、万方和中国知网（CNKI）数据库，截至 2023 年 1 月，使用以下 MeSH 术语：“盆腔器官脱垂”、“压力性尿失禁”和“阴道微环境”、“微环境”、“阴道清洁度”、“阴道炎”、“乳酸菌”和其他相关关键词。研究方法仅限于病例对照研究或横断面研究。使用纽卡斯尔-渥太华量表进行质量评估，并使用 Review Manager 5.3 对纳入文献进行荟萃分析。
本系统评价和荟萃分析共纳入 8 篇文章，共涉及 7298 名研究参与者。荟萃分析的汇总结果表明，阴道微环境（阴道乳酸菌数量、白带清洁度和阴道炎存在）在中国女性中均与盆腔功能性疾病有统计学显著相关性。
本综述表明，阴道微环境对中国女性 PFD 的发生有影响。
本系统评价（SR）和荟萃分析（MA）的方案已在 PROSPERO 数据库中注册，注册号为 CRD42023407251。
