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褪黑素通过 SIRT3 介导的 TFAM 去乙酰化促进线粒体自噬来减轻脓毒症诱导的急性肾损伤。

Melatonin attenuates sepsis-induced acute kidney injury by promoting mitophagy through SIRT3-mediated TFAM deacetylation.

机构信息

Department of Critical Care Medicine, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong, China.

Guangdong Provincial Key Laboratory of Cardiac Function and Microcirculation, School of Basic Medical Sciences, Southern Medical University, Guangzhou, Guangdong, China.

出版信息

Autophagy. 2024 Jan;20(1):151-165. doi: 10.1080/15548627.2023.2252265. Epub 2023 Aug 31.

DOI:10.1080/15548627.2023.2252265
PMID:37651673
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10761103/
Abstract

AKI

acute kidney injury; ATP: adenosine triphosphate; BUN: blood urea nitrogen; CLP: cecal ligation and puncture; eGFR: estimated glomerular filtration rate; H&E: hematoxylin and eosin staining; LCN2/NGAL: lipocalin 2; LPS: lipopolysaccharide; LTL: lotus tetragonolobus lectin; mKeima: mitochondria-targeted Keima; mtDNA: mitochondrial DNA; PAS: periodic acid - Schiff staining; RTECs: renal tubular epithelial cells; SAKI: sepsis-induced acute kidney injury; Scr: serum creatinine; SIRT3: sirtuin 3; TFAM: transcription factor A, mitochondrial; TMRE: tetramethylrhodamine.

摘要

AKI

急性肾损伤；ATP：三磷酸腺苷；BUN：血尿素氮；CLP：盲肠结扎和穿孔；eGFR：估计肾小球滤过率；H&E：苏木精和伊红染色；LCN2/NGAL：脂质运载蛋白 2；LPS：脂多糖；LTL：莲花生四糖凝集素；mKeima：线粒体靶向 Keima；mtDNA：线粒体 DNA；PAS：过碘酸-Schiff 染色；RTECs：肾小管上皮细胞；SAKI：脓毒症引起的急性肾损伤；Scr：血清肌酐；SIRT3：沉默信息调节因子 3；TFAM：线粒体转录因子 A；TMRE：四甲基罗丹明

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