2 型糖尿病患者的甘油三酯/高密度脂蛋白胆固醇比值与肌肉量的相关性。
The correlation of triglyceride/high-density lipoprotein cholesterol ratio with muscle mass in type 2 diabetes patients.
机构信息
Department of Central Laboratory and Mitochondrial Medicine Laboratory, Qilu Hospital (Qingdao), Cheeloo College of Medicine, Shandong University, Qingdao, China.
Department of Cadre Health Care, Qilu Hospital (Qingdao), Cheeloo College of Medicine, Shandong University, Qingdao, China.
出版信息
BMC Endocr Disord. 2023 Apr 26;23(1):93. doi: 10.1186/s12902-023-01349-8.
Abstract
OBJECTIVE
Triglyceride/high-density lipoprotein cholesterol (TG/HDL-C) ratio is correlated with metabolic diseases. The prevalence of sarcopenia is significantly higher in type 2 diabetes mellitus (T2DM) patients compared with healthy controls. The purpose of our study is to evaluate the correlation of TG/HDL-C ratio with muscle mass in T2DM patients.
METHOD
Our study consists of 1048 T2DM inpatients recruited from the department of endocrinology. Skeletal muscle index (SMI) was detected with a dual energy X-ray absorptiometry method. Low muscle mass was diagnosed using the criteria of SMI less than 7.0 kg/m (in male subjects) or 5.4 kg/m (in female subjects).
RESULT
The prevalence of low muscle mass was 20.9% and 14.5% in male and female groups respectively. SMI was correlated with TG/HDL ratio after adjustment for age, duration of diabetes, diastolic blood pressure (DBP), and HbA1c in male subgroup. In female subgroup, SMI was associated with TG/HDL ratio after adjustment for age and DBP.
CONCLUSION
Higher TG/HDL-C ratio is correlated with muscle mass in T2DM patients.
摘要
目的
甘油三酯/高密度脂蛋白胆固醇（TG/HDL-C）比值与代谢性疾病相关。与健康对照组相比，2 型糖尿病（T2DM）患者的肌肉减少症患病率明显更高。本研究旨在评估 T2DM 患者中 TG/HDL-C 比值与肌肉量的相关性。
方法
我们的研究纳入了 1048 名内分泌科的 T2DM 住院患者。使用双能 X 射线吸收法检测骨骼肌指数（SMI）。低肌肉量的诊断标准为 SMI 男性<7.0kg/m，女性<5.4kg/m。
结果
男性和女性组的低肌肉量患病率分别为 20.9%和 14.5%。在调整了年龄、糖尿病病程、舒张压（DBP）和糖化血红蛋白（HbA1c）后，男性亚组的 SMI 与 TG/HDL 比值相关。在女性亚组中，调整年龄和 DBP 后，SMI 与 TG/HDL 比值相关。
结论
T2DM 患者中较高的 TG/HDL-C 比值与肌肉量相关。
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