Department of Biology, York University, Toronto, ON M3J 1P3, Canada.
PrairieNeuro Research Centre, Kleysen Institute for Advanced Medicine, Health Sciences Centre, Winnipeg, MB R3E 0Z3, Canada; Department of Physiology and Pathophysiology, University of Manitoba, Winnipeg, MB R3E 0J9, Canada; The Children's Hospital Research Institute of Manitoba, Winnipeg, MB R3E 3P4, Canada; Program in Biomedical Engineering, University of Manitoba, Winnipeg, MB, Canada.
Trends Neurosci. 2023 Nov;46(11):971-985. doi: 10.1016/j.tins.2023.08.001. Epub 2023 Aug 29.
Synapse organizing proteins are multifaceted molecules that coordinate the complex processes of brain development and plasticity at the level of individual synapses. Their importance is demonstrated by the major brain disorders that emerge when their function is compromised. The mechanisms whereby the various families of organizers govern synapses are diverse, but converge on the structure, function, and plasticity of synapses. Therefore, synapse organizers regulate how synapses adapt to ongoing activity, a process central for determining the developmental trajectory of the brain and critical to all forms of cognition. Here, we explore how synapse organizers set the conditions for synaptic plasticity and the associated molecular events, which eventually link to behavioral features of neurodevelopmental and neuropsychiatric disorders. We also propose central questions on how synapse organizers influence network function through integrating nanoscale and circuit-level organization of the brain.
突触组织蛋白是多功能分子，可在单个突触水平上协调大脑发育和可塑性的复杂过程。当它们的功能受到损害时，会出现各种主要的大脑疾病，这证明了它们的重要性。各种组织蛋白家族调节突触的机制多种多样，但都集中在突触的结构、功能和可塑性上。因此，突触组织者调节突触如何适应持续的活动，这是决定大脑发育轨迹的核心过程，对所有形式的认知都至关重要。在这里，我们探讨了突触组织者如何为突触可塑性和相关的分子事件设定条件，这些事件最终与神经发育和神经精神障碍的行为特征联系在一起。我们还提出了关于突触组织者如何通过整合大脑的纳米尺度和电路水平组织来影响网络功能的核心问题。
