UCB Pharma, Slough, UK.
Health Outcomes Division, College of Pharmacy, The University of Texas at Austin, Austin, TX, USA.
Osteoporos Int. 2023 Dec;34(12):2121-2132. doi: 10.1007/s00198-023-06895-4. Epub 2023 Aug 31.
Fracture-related costs vary by country. A standardized methodology and presentations were proposed to fairly assess the economic burden of osteoporotic fracture. Results indicated substantial costs of osteoporotic fractures for pharmacy, hospitalization, emergency care, and outpatient visits in women aged ≥ 50 years in Australia, Germany, South Korea, Spain, and the USA.
The objective of this multinational, retrospective matched cohort study was to use a standardized methodology across different healthcare systems to estimate the burden of osteoporotic fracture (OF) in women aged ≥ 50 years in Australia, Germany, South Korea, Spain, and the USA.
Within each country, healthcare resource utilization and direct costs of care were compared between patients with newly identified OF and a propensity score-matched cohort without OF during follow-up periods of up to 5 years.
Across all five countries, the OF cohort had significantly higher rates and length of inpatient admissions compared with the non-OF cohort. In each country, the adjusted total costs of care ratio between OF and non-OF cohorts were significant. The adjusted cost ratios for pharmacy, inpatient care, emergency care, and outpatient visits were similarly higher in the OF cohort across countries.
The current study demonstrates the substantial economic burden of OF across different countries when compared with matched non-OF patients. The findings would assist stakeholders and policymakers in developing appropriate health policies.
骨折相关费用因国家而异。为了公平评估骨质疏松性骨折的经济负担，提出了一种标准化的方法和表述。结果表明，在澳大利亚、德国、韩国、西班牙和美国，≥50 岁女性的骨质疏松性骨折在药房、住院、急诊护理和门诊就诊方面的费用较高。
本项多国家、回顾性匹配队列研究的目的是在不同的医疗保健系统中使用标准化方法，估算澳大利亚、德国、韩国、西班牙和美国≥50 岁女性骨质疏松性骨折（OF）的负担。
在每个国家内，根据倾向评分匹配无 OF 的患者，在长达 5 年的随访期间比较新确诊 OF 患者与非 OF 患者的医疗资源利用和直接医疗成本。
在所有五个国家中，OF 队列的住院率和住院时间均显著高于非 OF 队列。在每个国家中，OF 和非 OF 队列之间的调整后总护理成本比均具有统计学意义。在各个国家中，OF 队列的药房、住院护理、急诊护理和门诊就诊的调整后成本比也明显更高。
与匹配的非 OF 患者相比，目前的研究表明不同国家的 OF 具有较大的经济负担。这些发现将有助于利益相关者和决策者制定适当的卫生政策。
