Department of Gastrointestinal Surgery, The Third Hospital of Hebei Medical University, Shijiazhuang, 050051, P.R. China.
Department of Clinical Medical College, Tianjin Medical University, Tianjin, P.R. China.
BMC Gastroenterol. 2023 Aug 31;23(1):294. doi: 10.1186/s12876-023-02928-8.
A meta-analysis study was performed to systematically assess the association between tea consumption and CRC risk.
Cochrane Library, Embase, PubMed, and Web of Science were retrieved to collect articles in English since 24 July 2023. Databases were searched and evaluated by two reviewers independently.We screened the literature based on inclusion and exclusion criteria. After determining the random effect model or fixed utility model based on a heterogeneity test, odds ratios (ORs) and 95% confidence intervals (CIs) were calculated.
We included fourteen articles in this meta-analysis. We analyzed the data using a random effect model to explore the association between tea consumption and CRC because of apparent heterogeneity (P < 0.001, I2 = 99.5%). The combined results of all tests showed that there is no statistically significant association between tea consumption and CRC risk (OR = 0.756, 95%CI = 0.470-1.215, P = 0.247). Subsequently, subgroup analysis and sensitivity analysis were performed. Excluding any single study, the overall results ranged from 0.73 (95%CI = 0.44-1.20) to 0.86 (95%CI = 0.53-1.40). It was determined that there was no significant publication bias between tea consumption and CRC risk (P = 0.064) by Egger's tests.
The results indicated that tea consumption may not be significantly associated with the development of CRC.
Tea reduces colon cancer risk by 24%, but the estimate is uncertain. The actual effect on risk can range from a reduction of 51% to an increase of 18%, but regional and population differences may cause differences.
进行了一项荟萃分析研究，以系统评估茶的摄入与 CRC 风险之间的关联。
检索 Cochrane Library、Embase、PubMed 和 Web of Science 中的英文文章，以收集自 2023 年 7 月 24 日以来的文章。由两位审阅者独立检索和评估数据库。我们根据纳入和排除标准筛选文献。在基于异质性检验确定随机效应模型或固定效用模型后，计算比值比（ORs）和 95%置信区间（CIs）。
我们将 14 篇文章纳入这项荟萃分析。由于明显的异质性（P<0.001，I2=99.5%），我们使用随机效应模型分析数据以探讨茶的摄入与 CRC 之间的关联。所有检验的综合结果表明，茶的摄入与 CRC 风险之间没有统计学显著关联（OR=0.756，95%CI=0.470-1.215，P=0.247）。随后进行了亚组分析和敏感性分析。排除任何一项单独研究，总结果范围从 0.73（95%CI=0.44-1.20）到 0.86（95%CI=0.53-1.40）。Egger 检验表明，茶的摄入与 CRC 风险之间不存在显著的发表偏倚（P=0.064）。
结果表明，茶的摄入与 CRC 的发生发展可能没有显著关联。
茶可降低结肠癌风险 24%，但估计结果不确定。实际风险降低幅度可能为 51%至 18%，但地区和人群差异可能会造成影响。
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