Faculty of Health Sciences and MoE Frontiers Science Center for Precision Oncology, University of Macau, Taipa, Macau SAR, 999078, China.
Small. 2024 Jan;20(1):e2304824. doi: 10.1002/smll.202304824. Epub 2023 Aug 31.
Mesenchymal stem cells (MSCs) are becoming hotspots for application in disease therapies recently, combining with biomaterials and drug delivery system. A major advantage of MSCs applied in drug delivery system is that these cells enable specific targeting and releasing of cargos to the disease sites. However, the potential tumor tropic effects of MSCs raised concerns on biosafety. To solve this problem, there are emerging methods of isolating cell membranes and developing nanoformulations to perform drug delivery, which avoids concerns on biosafety without disturbing the membrane functions of specific polarizing and locating. These cargoes are so called "nanoghosts." This review article summarizes the current applications of nanoghosts, the promising potential of MSCs to be applied in membrane isolation and nanoghost construction, and possible approaches to develop better drug delivery system harnessing from MSC ghost cell membranes.
间充质干细胞（MSCs）最近在疾病治疗中的应用成为热点，与生物材料和药物传递系统相结合。MSCs 应用于药物传递系统的一个主要优势是，这些细胞能够将货物靶向特定的疾病部位并进行释放。然而，MSCs 的潜在肿瘤趋向性效应引起了人们对生物安全性的关注。为了解决这个问题，出现了分离细胞膜和开发纳米制剂来进行药物传递的新兴方法，这些方法避免了对生物安全性的担忧，同时又不干扰特定极化和定位的膜功能。这些货物被称为“纳米幽灵”。本文综述了纳米幽灵的当前应用，MSCs 在膜分离和纳米幽灵构建中的应用的有前途的潜力，以及利用 MSC 幽灵细胞膜开发更好的药物传递系统的可能方法。
