Department of Neurology, Indiana University School of Medicine, Indianapolis, Indiana, USA.
Alzheimer's Therapeutic Research Institute, University of Southern California, San Diego, California, USA.
Alzheimers Dement. 2023 Nov;19 Suppl 9(Suppl 9):S29-S41. doi: 10.1002/alz.13434. Epub 2023 Aug 31.
The Rey Auditory Verbal Learning Test (RAVLT) is a useful neuropsychological test for describing episodic memory impairment in dementia. However, there is limited research on its utility in early-onset Alzheimer's disease (EOAD). We assess the influence of amyloid and diagnostic syndrome on several memory scores in EOAD.
We transcribed RAVLT recordings from 303 subjects in the Longitudinal Early-Onset Alzheimer's Disease Study. Subjects were grouped by amyloid status and syndrome. Primacy, recency, J-curve, duration, stopping time, and speed score were calculated and entered into linear mixed effects models as dependent variables.
Compared with amyloid negative subjects, positive subjects exhibited effects on raw score, primacy, recency, and stopping time. Inter-syndromic differences were noted with raw score, primacy, recency, J-curve, and stopping time.
RAVLT measures are sensitive to the effects of amyloid and syndrome in EOAD. Future work is needed to quantify the predictive value of these scores.
RAVLT patterns characterize various presentations of EOAD and EOnonAD Amyloid impacts raw score, primacy, recency, and stopping time Timing-based scores add value over traditional count-based scores.
Rey 听觉言语学习测验（RAVLT）是一种用于描述痴呆患者情景记忆损伤的有用神经心理学测试。然而，关于其在早发性阿尔茨海默病（EOAD）中的应用的研究有限。我们评估了淀粉样蛋白和诊断综合征对 EOAD 中几种记忆评分的影响。
我们转录了纵向早发性阿尔茨海默病研究中的 303 名受试者的 RAVLT 记录。受试者按淀粉样蛋白状态和综合征分组。计算了原始分数、首因、近因、J 曲线、持续时间、停止时间和速度评分，并作为因变量输入线性混合效应模型。
与淀粉样蛋白阴性受试者相比，阳性受试者的原始分数、首因、近因和停止时间存在影响。在原始分数、首因、近因、J 曲线和停止时间方面观察到了综合征之间的差异。
RAVLT 测量结果对 EOAD 和 EOnonAD 的淀粉样蛋白和综合征的影响敏感。需要进一步的工作来量化这些评分的预测价值。
RAVLT 模式描绘了 EOAD 和 EOnonAD 的各种表现形式，淀粉样蛋白影响原始分数、首因、近因和停止时间。基于时间的评分比传统的基于计数的评分更有价值。
