Binub Kanniyan, Harsha P V, Salim Roshni S, Sunny Sobin, Dabas Pratibha, Chalil Swathy, Henry Sneha
Department of Community Medicine, Malabar Medical College and Research Center, Calicut, Kerala, India.
Department of Pulmonary Medicine, Malabar Medical College and Research Center, Calicut, Kerala, India.
J Pharm Bioallied Sci. 2023 Jul;15(Suppl 1):S414-S418. doi: 10.4103/jpbs.jpbs_549_22. Epub 2023 Jul 5.
Laboratory testing has been extremely helpful in determining the severity and determining the course of treatment for COVID-19 patients. Our aim has been to look for variables of patient's clinical and laboratory profile for two weeks and to observe their significance. Observational, Cross-sectional study. Data from the clinic and laboratory were compiled on Google form after informed consent from the patient. Statistical analysis was done using the Mann-Whitney U and unpaired t test. Population statistics included 202 patients (1 week) and 161 patients (2 week), with the mean age of 61 ± 18 years. Most patients fell under the mild category (SPO2 >94%). High body mass index ( = 119) and hypertensive ( = 98) were the most common comorbidities observed. Diabetes, cardiovascular and respiratory diseases are the other comorbidities studied in this study. Hypoalbuminemia ( = 194) is the most deranged laboratory parameter in mild category, followed by lymphopenia ( = 109). In severe category also, hypoalbuminemia ( = 13) was deranged more. Other laboratory parameters included are CRP, D-Dimer, neutrophil and lymphocyte count. This study showed that albumin is a good predictor for estimating the severity of COVID-19 patients especially in the first week of their admission.
实验室检测在确定新冠肺炎患者的病情严重程度和治疗方案方面非常有帮助。我们的目的是在两周内寻找患者临床和实验室指标的变量，并观察其意义。观察性横断面研究。在获得患者知情同意后，通过谷歌表格收集临床和实验室数据。使用曼-惠特尼U检验和非配对t检验进行统计分析。总体统计包括202名患者（1周）和161名患者（2周），平均年龄为61±18岁。大多数患者属于轻症类别（血氧饱和度>94%）。观察到的最常见合并症是高体重指数（=119）和高血压（=98）。本研究还对糖尿病、心血管疾病和呼吸系统疾病等其他合并症进行了研究。低蛋白血症（=194）是轻症类别中最紊乱的实验室指标，其次是淋巴细胞减少（=109）。在重症类别中，低蛋白血症（=13）的紊乱情况也更严重。其他包括的实验室指标有CRP、D-二聚体、中性粒细胞和淋巴细胞计数。这项研究表明，白蛋白是评估新冠肺炎患者病情严重程度的良好预测指标，尤其是在入院的第一周。
