• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

[肝细胞中辅酶A强化生物合成过程中的细胞色素P-450依赖性反应]

[Cytochrome P-450-dependent reactions during intensified biosynthesis of coenzyme A in hepatocytes].

作者信息

Sushko L I, Sheĭbak V M, Abakumov G Z, Moĭseenok A K

出版信息

Vopr Med Khim. 1986 Jul-Aug;32(4):20-4.

PMID:3765494
Abstract

After subcutaneous administration into male rats of 4-phosphopantothenic acid and pantethine during 10 days at a dose equivalent to 30 mg/kg of calcium pantothenate total content of CoA was increased in liver tissue. Both these preparations activated the liver endoplasmic reticulum monooxygenase system mainly at the step of substrate hydroxylation. The phenomenon observed appears to occur due to activation of cytochrome P-450 biosynthesis and/or to alterations in phospholipid composition of microsomal membranes.

摘要

给雄性大鼠皮下注射4-磷酸泛酸和泛硫乙胺10天，剂量相当于30mg/kg泛酸钙，肝脏组织中辅酶A的总含量增加。这两种制剂主要在底物羟基化步骤激活肝脏内质网单加氧酶系统。观察到的现象似乎是由于细胞色素P-450生物合成的激活和/或微粒体膜磷脂组成的改变所致。

相似文献

1
[Cytochrome P-450-dependent reactions during intensified biosynthesis of coenzyme A in hepatocytes].[肝细胞中辅酶A强化生物合成过程中的细胞色素P-450依赖性反应]
Vopr Med Khim. 1986 Jul-Aug;32(4):20-4.
2
Pantethine and pantothenate effect on the CoA content of rat liver.泛硫乙胺和泛酸盐对大鼠肝脏辅酶A含量的影响。
Int J Vitam Nutr Res. 1984;54(2-3):211-6.
3
[Changes in the content of the thiol form of the acetylation coenzyme in the liver during administration of vitamin B3-active compounds to intact and locally irradiated animals].[在给未受照射和局部受照射动物施用维生素B3活性化合物期间肝脏中乙酰化辅酶硫醇形式含量的变化]
Radiobiologiia. 1984 May-Jun;24(3):353-5.
4
[Role of lipid peroxidation in the regulation of liver microsomal monooxygenase activity in homoiothermic animals exposed to cold].
Biull Eksp Biol Med. 1983 Jan;95(1):37-9.
5
[Coa biosynthesis and the structure of its reserve in the liver in mice with diabetes (db/db) after administration of pantothenic acid derivatives].[糖尿病（db/db）小鼠给予泛酸衍生物后肝脏中辅酶A生物合成及其储备结构]
Probl Endokrinol (Mosk). 1987 Nov-Dec;33(6):45-9.
6
Mechanisms of disassembly of a mixed function oxygenase system in liver endoplasmic reticulum: I. The role of peroxidation of membrane phospholipids.
Acta Physiol Pharmacol Bulg. 1984;10(2):73-81.
7
[Interrelation of the processes of lipid peroxidation and hydroxylation in the liver microsomal fraction of white rats with alloxan diabetes].
Vopr Med Khim. 1985 Mar-Apr;31(2):62-4.
8
[Relation of changes in the content and activity of rat liver microsomal cytochrome P-450 to the intensification of lipid peroxidation under stress].
Biull Eksp Biol Med. 1983 May;95(5):51-3.
9
[Oxidative processes and phospholipid metabolism in hepatocyte membranes during alloxan diabetes].[四氧嘧啶糖尿病期间肝细胞膜中的氧化过程和磷脂代谢]
Vopr Med Khim. 1990 Mar-Apr;36(2):10-2.
10
[Structural changes in the lipid component of membranes of endoplasmatic reticulum in early and late periods after liver ischemia].[肝脏缺血后早期和晚期内质网膜脂质成分的结构变化]
Vopr Med Khim. 1988 Jan-Feb;34(1):25-9.