Ivanova I L, Shchepin V A, Akulin V N
Vopr Pitan. 1986 Jul-Aug(4):48-50.
Hypercholesterolemia was experimentally induced in rats which received diets with a high fat content (66% calories) and cholesterol loading (2.5% of ration). The therapeutic effect of lipids isolated from quick-frozen Far East sardines was tested on rats given 500 mg lipids daily. The content of the blood serum lipid fractions in the test animals decreased under the action of the sardines' lipids: the total cholesterol level dropped by 23%, beta-lipoprotein cholesterol by 29%, triglycerides by 15%; the content of beta-lipoproteins became normal. The blood coagulation time was diminished in rats receiving diets with a high content of fat and cholesterol, as compared to that in control animals; and it increased under the action of sardines' lipids. A conclusion has been made on the hypolipidemic property of Far East sardines' lipids that produce a therapeutic effect on the blood lipid metabolism in animals.
通过给大鼠喂食高脂肪含量（66%热量）和胆固醇负荷（占日粮的2.5%）的饲料，在实验中诱导大鼠出现高胆固醇血症。对每天给予500毫克脂质的大鼠测试了从速冻远东沙丁鱼中分离出的脂质的治疗效果。在沙丁鱼脂质的作用下，试验动物血清脂质组分的含量降低：总胆固醇水平下降了23%，β-脂蛋白胆固醇下降了29%，甘油三酯下降了15%；β-脂蛋白的含量恢复正常。与对照动物相比，接受高脂肪和高胆固醇饮食的大鼠的血液凝固时间缩短；而在沙丁鱼脂质的作用下，血液凝固时间延长。已得出结论，远东沙丁鱼的脂质具有降血脂特性，对动物的血脂代谢有治疗作用。
