Wang Yizheng, Sounalet Thomas, Guertin Arnaud, Nigron Etienne, Michel Nathalie, Haddad Férid
Subatech, UMR 6457, IMT Atlantique, CNRS/IN2P3, Nantes Université, 4 rue Alfred Kastler BP20722, 44307, Nantes, Cedex 3, France.
Subatech, UMR 6457, IMT Atlantique, CNRS/IN2P3, Nantes Université, 4 rue Alfred Kastler BP20722, 44307, Nantes, Cedex 3, France.
Appl Radiat Isot. 2023 Nov;201:110996. doi: 10.1016/j.apradiso.2023.110996. Epub 2023 Aug 22.
The terbium (Tb) family has attracted much attention in recent years thanks to the diagnostic and therapeutic applications of the quadruplet Tb, Tb, Tb and Tb. However, the scarce availability of Tb radioisotopes is one of the main reasons hindering its clinical applications. To increase its availability, this work proposes to use enriched gadolinium (Gd) targets to produce some Tb radioisotopes (Tb, Tb, and Tb) via deuteron-induced reactions in cyclotrons. The production of the Auger and gamma emitter Tb was chosen as a case study because the Gd enrichment (92.8%) is the highest available from all Gd stable isotopes. The involved reaction is Gd(d,2n)Tb. Using enriched thin Gd-containing targets, cross-sections of the reactions Gd(d,x)Tb have been measured at the GIP ARRONAX cyclotron facility with a beam energy ranging from 8 MeV to 30 MeV. This measurement allows for estimating the production yield and the purity of Tb, and for determining the irradiation parameters for large production batches. A thick enriched GdO target has been then irradiated with an incident energy of 15.1 MeV and a beam current of 368 nA for 1 h. The production yield of Tb is 10.2 MBq/μA/h at End Of Bombardment (EOB) and the purity is 89% after 14 days of decay. These experimental values are consistent with estimation based on measured cross-sections. A comparison of the deuteron-induced and proton-induced production routes is also presented in this paper.
近年来，由于四联体铽（Tb）在诊断和治疗方面的应用，铽元素家族备受关注。然而，铽放射性同位素的稀缺是阻碍其临床应用的主要原因之一。为了提高其可得性，本研究提出利用富集钆（Gd）靶，通过回旋加速器中的氘核诱导反应来生产一些铽放射性同位素（Tb、Tb和Tb）。选择俄歇电子发射体和γ发射体Tb的生产作为案例研究，因为钆的富集度（92.8%）是所有钆稳定同位素中最高的。涉及的反应是Gd(d,2n)Tb。使用富集的含钆薄靶，在GIP ARRONAX回旋加速器设施上测量了Gd(d,x)Tb反应的截面，束流能量范围为8 MeV至30 MeV。该测量有助于估算Tb的产率和纯度，并确定大规模生产批次的辐照参数。然后，用15.1 MeV的入射能量和368 nA的束流对一个厚的富集GdO靶进行了1小时的辐照。轰击结束时（EOB）Tb的产率为10.2 MBq/μA/h，衰变14天后纯度为89%。这些实验值与基于测量截面的估算结果一致。本文还对氘核诱导和质子诱导的生产路线进行了比较。
