Dellepiane Gaia, Casolaro Pierluigi, Gottstein Alexander, Mateu Isidre, Scampoli Paola, Braccini Saverio
Albert Einstein Center for Fundamental Physics (AEC), Laboratory for High Energy Physics (LHEP), University of Bern, Sidlerstrasse 5, CH-3012 Bern, Switzerland.
Albert Einstein Center for Fundamental Physics (AEC), Laboratory for High Energy Physics (LHEP), University of Bern, Sidlerstrasse 5, CH-3012 Bern, Switzerland.
Appl Radiat Isot. 2023 Oct;200:110969. doi: 10.1016/j.apradiso.2023.110969. Epub 2023 Aug 2.
Tb is one of the most interesting radionuclides for theranostic applications. It is suitable for SPECT imaging and it can be used as a true diagnostic partner of the therapeutic Tb and Tb. Its production by proton irradiation using enriched Gd and Gd oxide targets is currently being investigated and represents a promising solution. To achieve the level of radionuclidic purity required in the clinical setting, the co-production of Tb impurities has to be minimized. For this purpose, an accurate knowledge of the cross sections of the nuclear reactions involved is of paramount importance. In this paper, we report on the assessment of cross sections of the reactions Gd(p,xn)Tb, Gd(p,xn)Tb, Gd(p,xn)Tb and Gd(p,2n)Tb derived with a specific data analysis procedure developed by our group. This method allows to disentangle the nuclear contributions from the production cross section by inverting linear systems of equations and it requires the measurement of the cross sections from as many materials as the reactions involved in the production of the radionuclide under study. For this purpose, the experimental data previously measured by our group at the Bern medical cyclotron by irradiating natural GdO, enriched GdO and enriched GdO targets were used. For some of these nuclear reactions, cross sections were assessed for the first time. On the basis of our findings, production yield and purity can be calculated for any kind of isotopic composition of the enriched material.
铽是用于诊疗应用的最有趣的放射性核素之一。它适用于单光子发射计算机断层显像（SPECT）成像，并且可作为治疗性铽和铽的真正诊断伙伴。目前正在研究使用富集的钆和钆氧化物靶通过质子辐照来生产铽，这是一个很有前景的解决方案。为达到临床环境所需的放射性核素纯度水平，必须将铽杂质的共产生量降至最低。为此，准确了解所涉及核反应的截面至关重要。在本文中，我们报告了对通过我们小组开发的特定数据分析程序得出的反应钆（p，xn）铽、钆（p，xn）铽、钆（p，xn）铽和钆（p，2n）铽的截面评估。这种方法通过求解线性方程组的逆来从生产截面中分离出核贡献，并且需要测量与所研究放射性核素生产中涉及的反应一样多的材料的截面。为此，使用了我们小组先前在伯尔尼医用回旋加速器上通过辐照天然氧化钆、富集氧化钆和富集钆靶测量的实验数据。对于其中一些核反应，首次评估了截面。根据我们的研究结果，可以针对富集材料任何种类的同位素组成计算生产产率和纯度。
