Radkhah Nima, Zarezadeh Meysam, Jamilian Parmida, Ostadrahimi Alireza
Nutrition Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
Student Research Committee, Department of Clinical Nutrition, Faculty of Nutrition and Food Sciences, Tabriz University of Medical Sciences, Tabriz, Iran.
Adv Nutr. 2023 Nov;14(6):1479-1498. doi: 10.1016/j.advnut.2023.08.012. Epub 2023 Aug 30.
According to published meta-analyses, vitamin D exerts different beneficial effects in preventing and controlling risk factors associated with noncommunicable chronic diseases; however, the results are still conflicting. The purpose of this umbrella meta-analysis was to investigate the effect of vitamin D supplementation on low-density lipoprotein cholesterol, high-density lipoprotein (HDL) cholesterol, total cholesterol (TC), and triglyceride (TG) as components of the lipid profile. PubMed, Scopus, Web of Science, and Cochrane Database of Systematic Reviews were systematically searched for meta-analyses of randomized controlled trials. The umbrella meta-analysis followed the PRISMA guidelines. The random-effects model was employed to estimate the overall effect size (ES). Overall, 25 meta-analyses were included. In the standardized mean difference analysis, vitamin D significantly decreased TG (ES: -0.15; 95% CI: -0.23, -0.08; P ≤ 0.001) and TC levels (ES: -0.17; 95% CI: -0.23, -0.11; P ≤ 0.001) and increased HDL levels (ES: 0.08; 95% CI: 0.01, 0.15; P = 0.025). In the weighted mean difference analysis, vitamin D significantly decreased only TG levels (ES: -4.63 mg/dL; 95% CI: -7.70, -1.57; P = 0.003). The present study supports that vitamin D supplementation could be considered a beneficial adjuvant therapy in managing lipid profile levels, especially in individuals with vitamin D deficiency. This systematic review was registered in PROSPERO as CRD42022306334.
根据已发表的荟萃分析，维生素D在预防和控制与非传染性慢性病相关的危险因素方面发挥着不同的有益作用；然而，结果仍存在矛盾。这项汇总荟萃分析的目的是研究补充维生素D对作为血脂谱组成部分的低密度脂蛋白胆固醇、高密度脂蛋白（HDL）胆固醇、总胆固醇（TC）和甘油三酯（TG）的影响。系统检索了PubMed、Scopus、科学网和Cochrane系统评价数据库，以查找随机对照试验的荟萃分析。汇总荟萃分析遵循PRISMA指南。采用随机效应模型估计总体效应量（ES）。总体而言，纳入了25项荟萃分析。在标准化均数差分析中，维生素D显著降低了TG水平（ES：-0.15；95%CI：-0.23，-0.08；P≤0.001）和TC水平（ES：-0.17；95%CI：-0.23，-0.11；P≤0.001），并提高了HDL水平（ES：0.08；95%CI：0.01，0.15；P=0.025）。在加权均数差分析中，维生素D仅显著降低了TG水平（ES：-4.63mg/dL；95%CI：-7.70，-1.57；P=0.003）。本研究支持补充维生素D可被视为管理血脂谱水平的有益辅助治疗，尤其是在维生素D缺乏的个体中。这项系统评价已在PROSPERO中注册，注册号为CRD42022306334。
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