Department of Family Medicine, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan.
Research Center for Precision Environmental Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan.
Sci Rep. 2023 Sep 1;13(1):14393. doi: 10.1038/s41598-023-41513-7.
The objective of this study is to investigate the relationship between metabolic syndrome (MetS), and bone density in a 30- to 50-year-old Taiwanese population, and to explore the combined effects of BMI and health behaviors on this association. A total of 52,912 individuals aged 30-50 years from the Taiwan Biobank were included in this cross-sectional study. Bone density status was assessed using quantitative ultrasound (QUS). The joint effect was assessed by including an interaction term in the multi-logistic regression models to test the association between MetS, BMI, and bone density while controlling for potential confounders. MetS was associated with reduced bone density, with the risk of severe low bone density (SLBD) higher among BMI < 24 kg/m individuals with MetS (adjusted odds ratio [aOR] 1.5, 95% confidence interval [CI] 1.09-2.16), while the risk was not significant among BMI ≥ 24 kg/m individuals with MetS. Smoking, alcohol consumption, and lack of regular exercise among individuals with a BMI < 24 kg/m and MetS were associated with higher risk of severe low bone density (SLBD), the aORs (95%CI) were 2.9 (1.59-5.20), 2.1 (1.06-4.22), and 1.8 (1.24-2.54) respectively. Our study suggests that metabolic syndrome could increase the risk of severe low bone density, but this risk can be minimized through higher BMI, non-smoking, no alcohol consumption, and regular exercise. Conversely, smoking, alcohol consumption or lack of regular exercise may exacerbate the risk of severe low bone density. These findings highlight the importance of a multifactorial approach in managing bone healthcare.
本研究旨在探讨代谢综合征（MetS）与 30-50 岁台湾人群骨密度之间的关系，并探讨 BMI 和健康行为对这种关联的综合影响。本横断面研究共纳入了来自台湾生物库的 52912 名 30-50 岁的个体。骨密度状况采用定量超声（QUS）进行评估。采用多逻辑回归模型中的交互项来评估联合效应，以检验 MetS、BMI 和骨密度之间的关联，同时控制潜在的混杂因素。MetS 与骨密度降低相关，BMI<24kg/m的 MetS 个体发生严重低骨密度（SLBD）的风险更高（校正优势比[aOR] 1.5，95%置信区间[CI] 1.09-2.16），而 BMI≥24kg/m 的 MetS 个体中则无显著相关性。BMI<24kg/m 的 MetS 个体中，吸烟、饮酒和缺乏规律运动与严重低骨密度（SLBD）的风险增加相关，校正优势比（95%CI）分别为 2.9（1.59-5.20）、2.1（1.06-4.22）和 1.8（1.24-2.54）。本研究表明，代谢综合征可能会增加严重低骨密度的风险，但通过较高的 BMI、不吸烟、不饮酒和规律运动可以降低这种风险。相反，吸烟、饮酒或缺乏规律运动可能会加重严重低骨密度的风险。这些发现强调了在管理骨骼健康护理方面采取多因素方法的重要性。
