健康生活方式评分与伊朗成年人代谢综合征风险的关联：一项横断面研究。

The association between healthy lifestyle score and risk of metabolic syndrome in Iranian adults: a cross-sectional study.

机构信息

Department of Community Nutrition, Faculty of Nutrition, Tabriz University of Medical Sciences, Tabriz, Iran.

Nutrition Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.

出版信息

BMC Endocr Disord. 2023 Jan 17;23(1):16. doi: 10.1186/s12902-023-01270-0.

DOI:10.1186/s12902-023-01270-0

PMID:36647030

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9843981/

Abstract

BACKGROUND

Lifestyle risk factors, such as obesity, physical inactivity, smoking, and having an unhealthy diet are significantly associated to the risk of developing metabolic diseases such as type 2 diabetes, insulin resistance, and metabolic syndrome (MetS). Consequently, it is important to examine multiple lifestyle risk factors instead of single ones. Moreover, the combined effects of these factors on risk of MetS are not fully investigated. This study investigated the relationship between HLS and MetS and its components among apparently healthy adults living in Tabriz-Iran.

METHODS

This cross-sectional study includes 347 apparently healthy adults aged 20-50. To assess healthy lifestyle, four habits were used to examine HLS: physical activity (PA), smoking, healthy eating index-2015 (HEI-2015), and body mass index (BMI). Smoking status, PA, and dietary intakes (147-item) of study participants were evaluated using valid questionnaires. The lifestyle score ranged from zero (non-healthy) to four (most healthy) points. Binary logistic regression with adjusted models was used to examine the association of HLS and MetS, and its components. P < 0.05 was considered statistically significant.

RESULTS

In the current study, the average age and BMI of study participants were 40.78 ± 9.23 years old and 29.23 ± 5.97 kg/m, respectively. Participants in the highest quartile of HLS had significantly lower waist circumference (WC), BMI, weight, and had less fasting blood sugar (FBS), and triglyceride (TG) compared to the lowest quartile of HLS. Individuals in the second quartile of HLS had 24% greater odds for having MetS compared with those in the first quartile (adjusted OR: 1.24; 95% CI: 1.05-2.66). A significant reduction in hyperglycemia (adjusted OR: 0.85, 95% CI: 0.55-0.96) and high TG (adjusted OR: 0.83; 95% CI: 0.55-0.93) risk was also observed in the highest category of HLS compared to the lowest category. Moreover, after taking potential confounders into account, low score of HLS was associated with increased odds of MetS in women (adjusted OR: 1.32; 95% CI: 1.03-2.91).

CONCLUSION

The results showed that the lowest adherence to HLS was associated with higher odds MetS in women, after adjusting for all covariates. Moreover, adherence to a healthy lifestyle was related to lower odds of hyperglycemia and high TG in Iranian adults. To confirm these results, prospective studies are required.

摘要

背景

生活方式风险因素，如肥胖、身体活动不足、吸烟和不健康饮食，与 2 型糖尿病、胰岛素抵抗和代谢综合征（MetS）等代谢疾病的风险显著相关。因此，检查多种生活方式风险因素而不是单一因素很重要。此外，这些因素对 MetS 风险的综合影响尚未得到充分研究。本研究旨在探讨伊朗大不里士市 20-50 岁的健康成年人中 HLS 与 MetS 及其成分之间的关系。

方法

本横断面研究包括 347 名健康成年人。为了评估健康的生活方式，使用四种习惯来评估 HLS：身体活动（PA）、吸烟、健康饮食指数-2015（HEI-2015）和体重指数（BMI）。使用有效的问卷评估研究参与者的吸烟状况、PA 和饮食摄入量（147 项）。生活方式评分范围从 0（非健康）到 4（最健康）。使用调整后的模型进行二元逻辑回归，以检验 HLS 与 MetS 及其成分的相关性。P<0.05 被认为具有统计学意义。

结果

在本研究中，研究参与者的平均年龄和 BMI 分别为 40.78±9.23 岁和 29.23±5.97kg/m2。与 HLS 最低四分位的参与者相比，HLS 最高四分位的参与者的腰围（WC）、BMI、体重、空腹血糖（FBS）和甘油三酯（TG）均显著降低。与 HLS 第一四分位相比，HLS 第二四分位的个体患 MetS 的几率增加了 24%（调整后的 OR：1.24；95%CI：1.05-2.66）。与最低类别相比，HLS 最高类别还观察到高血糖（调整后的 OR：0.85，95%CI：0.55-0.96）和高 TG（调整后的 OR：0.83；95%CI：0.55-0.93）风险显著降低。此外，在考虑所有混杂因素后，低 HLS 评分与女性 MetS 发病风险增加相关（调整后的 OR：1.32；95%CI：1.03-2.91）。