School of Nursing Sciences, The Academic College of Tel-Aviv-Yaffa, 2 Rabenu Yerucham St., P.O.B 8401, 61083, Tel Aviv, Israel.
Internal Medicine C, Meir Medical Center, Kfar Saba, Israel.
Clin Exp Med. 2023 Dec;23(8):4891-4899. doi: 10.1007/s10238-023-01172-4. Epub 2023 Sep 1.
Coronavirus disease (COVID-19) is highly transmissible between human beings. We examined differences in the core families with COVID-19 severity and mortality and comorbidities between Arab and Jews and explored the factors associated with COVID-19 severity and mortality to find a genetic component. A cross-sectional study was conducted among 2240 COVID-19 patients (> 18 years of age) randomly selected by online panels and questionnaires in the native language (Hebrew or Arabic) during March 2021-June 2022. Multivariable linear regression models were used to assess correlations with COVID-19 disease severity and mortality. Overall, 1549 (69%) were Arabs and 691 (31%) were Jews. The proportion of participants who died from COVID-19 was higher among Arabs compared with Jews (66% vs. 59%), P < 0.001. The mean number of deaths from COVID-19 and patients with severe COVID-19 was higher in ultra-Orthodox Jewish, non-academic core families and those who lived in the city residence compared with secular, academic core families and who live in the village residence, P < 0.001. A multivariable linear regression model showed a significant association between metabolic, kidney, cardiovascular, and respiratory diseases with COVID-19 severity (B coefficient - 0.43, B coefficient - 0.53, B coefficient - 0.53, B coefficient - 0.42, respectively) and COVID-19 mortality (B coefficient - 0.51, B coefficient - 0.64, B coefficient - 0.67, B coefficient - 0.34, respectively), P < 0.001. COVID-19 severity and mortality were highly associated with comorbidities, ethnicity, social and environmental factors. Furthermore, we believe that genetic factors also contribute to the increase in COVID-19 severity and mortality and the differences rates of these between Arabs and Jews in Israel.
冠状病毒病 (COVID-19) 在人与人之间具有高度传染性。我们研究了 COVID-19 严重程度和死亡率以及合并症在阿拉伯人和犹太人核心家庭之间的差异，并探讨了与 COVID-19 严重程度和死亡率相关的因素，以寻找遗传因素。2021 年 3 月至 2022 年 6 月期间，我们在在线小组中随机选择了 2240 名 COVID-19 患者（年龄>18 岁）进行了横断面研究，他们以母语（希伯来语或阿拉伯语）填写了问卷。我们使用多变量线性回归模型来评估与 COVID-19 疾病严重程度和死亡率的相关性。总的来说，1549 名（69%）是阿拉伯人，691 名（31%）是犹太人。与犹太人相比，阿拉伯人死于 COVID-19 的比例更高（66%比 59%），P<0.001。死于 COVID-19 的患者人数和 COVID-19 重症患者人数在极端正统派犹太教、非学术核心家庭和居住在城市的人群中更高，而在世俗、学术核心家庭和居住在农村的人群中则较低，P<0.001。多变量线性回归模型显示，代谢、肾脏、心血管和呼吸系统疾病与 COVID-19 严重程度（B 系数-0.43、B 系数-0.53、B 系数-0.53、B 系数-0.42）和 COVID-19 死亡率（B 系数-0.51、B 系数-0.64、B 系数-0.67、B 系数-0.34）之间存在显著关联，P<0.001。COVID-19 的严重程度和死亡率与合并症、种族、社会和环境因素高度相关。此外，我们认为遗传因素也导致了 COVID-19 严重程度和死亡率的增加，以及以色列阿拉伯人和犹太人之间这些比率的差异。
