Hackler J
Z Kinder Jugendpsychiatr. 1986;14(3):220-7.
A young adolescent girl (13.5 years old) with a compulsive eating disorder and gross obesity was treated with a combination of behavior therapy and fenfluramine (Ponderax). The behavior modification program used was adapted from Reiss's program, an approach that had proven effective in individuals with hyperphagia and overweight who had no additional emotional problems or brain damage. In our patient the problem was complicated by the presence of autism, with compulsive eating being particularly ingrained as a form of stereotyped behavior. We therefore decided to administer fenfluramine concurrently because it is known to have both an appetite-depressing effect and a positive effect on behavioral disturbances characteristic of autistic individuals. During inpatient treatment the girl lost weight and showed changes in behavior. The changed eating behavior was still being maintained many months after discharge and after fenfluramine had been discontinued. We assume that drug treatment provided an important kind of support for the behavioral treatment program. Further, we attribute the emotional stabilization in this autistic girl to fenfluramine. We now plan to extend this treatment approach to other subjects with similar problems.
一名患有强迫性进食障碍和严重肥胖症的青春期少女（13.5岁）接受了行为疗法和芬氟拉明（Ponderax）联合治疗。所采用的行为矫正方案改编自赖斯的方案，该方法已被证明对没有其他情感问题或脑损伤的食欲亢进和超重个体有效。在我们的患者中，问题因自闭症的存在而变得复杂，强迫性进食作为一种刻板行为形式尤为根深蒂固。因此，我们决定同时给予芬氟拉明，因为已知它既有抑制食欲的作用，又对自闭症个体特有的行为障碍有积极作用。在住院治疗期间，女孩体重减轻，行为也有变化。出院后许多个月，在停用芬氟拉明后，改变的进食行为仍得以维持。我们认为药物治疗为行为治疗方案提供了一种重要的支持。此外，我们将这名自闭症女孩的情绪稳定归因于芬氟拉明。我们现在计划将这种治疗方法推广到其他有类似问题的受试者身上。
