Department of Psychiatry, College of Medicine, Chung-Ang University, Seoul, Republic of Korea.
Department of Internal Medicine, College of Medicine, Chung-Ang University, Seoul, Republic of Korea.
Maturitas. 2023 Dec;178:107827. doi: 10.1016/j.maturitas.2023.107827. Epub 2023 Aug 23.
Menopause presents various physical and psychological disturbances for women and comes at a high financial cost. Therefore, this study aimed to identify factors influencing menopause symptoms.
Data of Korean perimenopausal women aged 40-60 (n = 1060; mean age, 46.03 ± 4.08) were collected by a research company. Participants were classified into a "functional" group (n = 716) or a "dysfunctional" group (n = 344) according to the severity of their perimenopausal psychosomatic symptoms. To investigate the association of obstetric and psychiatric history with membership of the "dysfunctional" group, a hierarchical logistic regression analysis was conducted.
The outcomes of all three hierarchical logistic regression models presented significant overall model fit. Among the independent variables, family history of menopausal symptoms, menarcheal age, number of pregnancies, history of postpartum depression, postpartum psychosis, and other psychiatric disorders were positively associated with being in the "dysfunctional" group, whereas age and number of deliveries were negatively associated with being in the "dysfunctional" group.
A short reproductive period and short exposure to estrogen due to late menarche and early menopausal transition may be related to severe perimenopausal symptoms. The relationship between the history of postpartum mental illness and severe perimenopausal symptoms may be associated with heightened sensitivity to hormonal triggers when a woman is exposed to fluctuating ovarian sex steroid levels. The relationship between parity or gravidity and the severity of menopausal symptoms in Korean women differed from that in studies conducted in other countries, possibly due to the low birth rate in Korea.
绝经会给女性带来各种身体和心理上的不适，同时也会带来高昂的经济成本。因此，本研究旨在确定影响绝经症状的因素。
本研究通过一家研究公司收集了韩国 40-60 岁围绝经期女性（n=1060；平均年龄 46.03±4.08 岁）的数据。根据围绝经期身心症状的严重程度，将参与者分为“功能性”组（n=716）或“非功能性”组（n=344）。为了研究产科和精神病史与“非功能性”组成员的关系，进行了分层逻辑回归分析。
所有三个分层逻辑回归模型的结果均呈现出显著的整体模型拟合度。在独立变量中，家族绝经症状史、初潮年龄、妊娠次数、产后抑郁症史、产后精神病和其他精神障碍史与处于“非功能性”组呈正相关，而年龄和分娩次数与处于“非功能性”组呈负相关。
初潮年龄晚和绝经过渡早导致的生育期短和雌激素暴露时间短，可能与绝经前期症状严重有关。产后精神病史与严重绝经前期症状之间的关系可能与女性暴露于波动的卵巢性激素水平时对激素触发的敏感性增加有关。韩国女性的生育史或孕次与绝经症状严重程度之间的关系与其他国家的研究结果不同，这可能是由于韩国的低生育率所致。
