利用循环微生物 DNA 进行早期癌症检测。
Leveraging circulating microbial DNA for early cancer detection.
机构信息
Cancer Bioinformatics, School of Cancer & Pharmaceutical Sciences, Faculty of Life Sciences and Medicine, King's College London, London, UK; Centre for Host-Microbiome Interactions, Faculty of Dentistry, Oral & Craniofacial Sciences, King's College London, London, UK; School of Cancer & Pharmaceutical Sciences, Faculty of Life Sciences and Medicine, King's College London, London, UK.
Centre for Host-Microbiome Interactions, Faculty of Dentistry, Oral & Craniofacial Sciences, King's College London, London, UK; Science for Life Laboratory, KTH - Royal Institute of Technology, Stockholm, Sweden.
出版信息
Trends Cancer. 2023 Nov;9(11):879-882. doi: 10.1016/j.trecan.2023.08.001. Epub 2023 Sep 1.
Microbial cell-free DNA (microbial cfDNA) offers a minimally invasive approach for profiling the microbiome. Despite technical and biological challenges, the potential of microbial cfDNA for cancer detection is increasingly being evaluated using deep sequencing, novel laboratory approaches, and computational methods. Targeting the microbiome using liquid biopsies could improve early cancer detection.
微生物无细胞 DNA（microbial cfDNA）为微生物组分析提供了一种微创的方法。尽管存在技术和生物学方面的挑战，但使用深度测序、新型实验室方法和计算方法评估微生物 cfDNA 用于癌症检测的潜力正在不断增加。使用液体活检靶向微生物组可以提高癌症的早期检测率。
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