Solem J O, Tengborn L, Olin C, Steen S
Acta Chir Scand. 1986 Jun-Jul;152:427-32.
An experimental model for controlled massive bleeding in pigs was developed to evaluate a new method for intraoperative autotransfusion of concentrated whole blood. The animals were injured in the descending thoracic aorta, creating a massive bleeding into the left pleural cavity. By means of a new system for autotransfusion, the animals were kept alive by retransfusing the blood at the same rate as it was shed. All animals were in good condition after autotransfusion of bleeding corresponding to three blood volumes. The postoperative hematological status including hemoglobin, hematocrit, platelet counts and electrolytes was not significantly different from the values before the experiment. The coagulation assays, including platelet adhesiveness, were normal after the experiment. In one pig the urine was positive for hemoglobin using a Hemostix test although it was macroscopically clear. This new method allows autotransfusion of whole blood with a desired hematocrit, with intact platelets and coagulation factors.
建立了猪可控性大量出血的实验模型，以评估一种术中自体浓缩全血回输的新方法。动物的降主动脉受到损伤，导致大量血液流入左胸腔。通过一种新的自体输血系统，以与失血相同的速率回输血液，使动物存活下来。在回输相当于三个血容量的失血后，所有动物状况良好。术后血液学指标，包括血红蛋白、血细胞比容、血小板计数和电解质，与实验前的值无显著差异。实验后包括血小板黏附性在内的凝血检测均正常。在一只猪中，尽管肉眼观察尿液清澈，但使用Hemostix试纸检测显示尿液血红蛋白呈阳性。这种新方法允许回输具有所需血细胞比容、血小板和凝血因子完整的全血。
