癌症相关成纤维细胞在治疗抵抗中的潜在机制。

Potential mechanisms of cancer-associated fibroblasts in therapeutic resistance.

机构信息

Department of Pathology, Affiliated Cancer Hospital of Dalian University of Technology (Liaoning Cancer Hospital and Institute, Cancer Hospital of China Medical University), Shenyang, China.

Tumor Etiology and Screening Department of Cancer Institute and General Surgery, The First Hospital of China Medical University, Shenyang, China; Key Laboratory of Cancer Etiology and Prevention in Liaoning Education Department, The First Hospital of China Medical University, Shenyang, China; Key Laboratory of GI Cancer Etiology and Prevention in Liaoning Province, The First Hospital of China Medical University, Shenyang, China.

出版信息

Biomed Pharmacother. 2023 Oct;166:115425. doi: 10.1016/j.biopha.2023.115425. Epub 2023 Sep 4.

DOI:10.1016/j.biopha.2023.115425

PMID:37660643

Abstract

Despite continuous improvements in research and new cancer therapeutics, the goal of eradicating cancer remains elusive because of drug resistance. For a long time, drug resistance research has been focused on tumor cells themselves; however, recent studies have found that the tumor microenvironment also plays an important role in inducing drug resistance. Cancer-associated fibroblasts (CAFs) are a main component of the tumor microenvironment. They cross-talk with cancer cells to support their survival in the presence of anticancer drugs. This review summarizes the current knowledge of the role of CAFs in tumor drug resistance. An in-depth understanding of the mechanisms underlying the cross-talk between CAFs and cancer cells and insight into the importance of CAFs in drug resistance can guide the development of new anticancer strategies.

摘要

尽管在癌症研究和新的癌症治疗方法方面取得了持续的进展，但由于耐药性的存在，消除癌症的目标仍然难以实现。长期以来，耐药性研究一直集中在肿瘤细胞本身；然而，最近的研究发现，肿瘤微环境也在诱导耐药性方面起着重要作用。癌相关成纤维细胞（CAFs）是肿瘤微环境的主要组成部分。它们与癌细胞相互作用，以支持它们在抗癌药物存在的情况下存活。这篇综述总结了 CAFs 在肿瘤耐药性中的作用的现有知识。深入了解 CAFs 与癌细胞之间的相互作用的机制，并认识到 CAFs 在耐药性中的重要性，可以指导新的抗癌策略的发展。