Department of Gastroenterological Surgery, Graduate School of Medical Sciences, Kumamoto University, Kumamoto, Japan.
Gastrointestinal Cancer Biology, International Research Center of Medical Sciences (IRCMS), Kumamoto University, Kumamoto, Japan.
Cancer Sci. 2020 Oct;111(10):3468-3477. doi: 10.1111/cas.14578. Epub 2020 Aug 11.
The effectiveness of current chemotherapies for cancer is gradually progressing; however achieving a complete cure through chemotherapy is still difficult and has been the main goal in treatment of advanced cancer. Drug resistance is an issue in cancer therapy, therefore increasing numbers of investigations into drug resistance have focused on the characteristics of the cancer cells themselves. The interaction between the tumor microenvironment (TME) and cancer cells is also intimately involved in the development of drug resistance. Cancer-associated fibroblasts (CAFs) are a predominant component of the TME and affect tumor progression by secreting soluble factors. This review summarizes the most up-to-date knowledge of CAFs and drug resistance in cancer, with a focus on factors secreted from CAFs including proteins, cytokines, extracellular vesicles, and metabolites. A perspective on the potential role of anti-CAF therapies in overcoming CAF-induced drug resistance is also discussed.
目前癌症的化疗效果正在逐步提高；然而，通过化疗实现完全治愈仍然很困难，这也是治疗晚期癌症的主要目标。耐药性是癌症治疗中的一个问题，因此越来越多的耐药性研究集中在癌细胞本身的特征上。肿瘤微环境（TME）与癌细胞之间的相互作用也与耐药性的发展密切相关。癌症相关成纤维细胞（CAFs）是 TME 的主要组成部分，通过分泌可溶性因子影响肿瘤的进展。本综述总结了 CAFs 与癌症耐药性的最新知识，重点介绍了 CAFs 分泌的包括蛋白质、细胞因子、细胞外囊泡和代谢物在内的多种因子。本文还探讨了抗 CAFs 治疗在克服 CAFs 诱导的耐药性方面的潜在作用。
