He B J, Liu Z K, Shen P, Sun Y X, Chen B, Zhan S Y, Lin H B
Department of Epidemiology and Biostatistics, Peking University School of Public Health, Beijing 100191, China.
Yinzhou District Center for Disease Control and Prevention, Ningbo 315199, Zhejiang, China.
Beijing Da Xue Xue Bao Yi Xue Ban. 2022 Jun 18;54(3):511-519. doi: 10.19723/j.issn.1671-167X.2022.03.017.
To describe the distribution characteristics of inflammatory bowel disease among permanent residents in Yinzhou District, Ningbo City, and to understand the disease burden and development trend of inflammatory bowel disease in this area.
Using the retrospective cohort design, we collected the registration information of all permanent residents in the residents' health files of the Yinzhou Regional Health Information Platform from 2010 to 2020, and used electronic medical records to follow up their inflammatory bowel disease visits. A one-year wash-out period was set, and the patients who were diagnosed with the primary diagnosis for the first time after one year of registration were re-garded as new cases. The incidence density and 95% confidence interval () of inflammatory bowel disease were estimated by Poisson distribution.
From 2011 to 2020, a total of 1 496 427 permanent residents in Yinzhou District were included, of which 729 996 were male (48.78%). The total follow-up person-years were 8 081 030.82, and the median follow-up person-years were 5.41 [interquartile range (): 5.29]. During the study period, there were 1 217 new cases of inflammatory bowel disease, of which males (624 cases, 51.27%) were more than females (593 cases, 48.73%). The total incidence density was 15.06/100 000 person-years (95%: 14.23, 15.93). Among all new cases, there were 1 106 cases (90.88%) of ulcerative colitis, with an incidence density of 13.69 per 100 000 person-years (95%: 12.89, 14.52); 70 cases (5.75%) of Crohn's disease, with an incidence density of 0.87 per 100 000 person-years (95%: 0.68, 1.09); and 41 cases (3.37%) of indeterminate colitis, with an incidence density of 0.51 per 100 000 person-years (95%: 0.36, 0.69). The median age of onset of ulcerative colitis was 50.82 years old (: 18.77), with the highest proportion (15.01%) in the 45-49 years group. The incidence density of ulcerative colitis gradually increased with age, reaching a relatively high level in the 45-49 years group (20.53/100 000 person-years; 95%: 17.63, 23.78), followed by a slight increase. And the incidence density in the 65-69 years group was the highest (25.44/100 000 person-years; 95%: 20.85, 30.75), with a rapid decrease in the 75-79 years group. The median age of onset of Crohn's disease was 44.34 years (: 33.41), with the highest proportion (12.86%) in the 25-29 years group. Due to the small number of new cases of Crohn's disease, the age distribution fluctuated greatly, with peaks both in young and old people. From 2011 to 2020, the incidence density of inflammatory bowel disease in Yinzhou District was at a low level from 2011 to 2013, and showed a rapid upward trend from 2014 to 2016, reaching a peak of 24.62 per 100 000 person-years in 2016 (95%: 21.31, 28.30), and slightly decreased in 2017-2020.
The incidence density of inflammatory bowel disease in Yinzhou District from 2011 to 2020 was at a relatively high level, and medical institutions and health departments need to pay attention to the burden of disease caused by it.
描述宁波市鄞州区常住人口中炎症性肠病的分布特征，了解该地区炎症性肠病的疾病负担及发展趋势。
采用回顾性队列设计，收集鄞州区区域卫生信息平台居民健康档案中2010年至2020年所有常住人口的登记信息，并利用电子病历对其炎症性肠病就诊情况进行随访。设定一年的洗脱期，将登记一年后首次诊断为原发性诊断的患者视为新发病例。采用泊松分布估计炎症性肠病的发病密度及95%置信区间（）。
2011年至2020年，共纳入鄞州区常住人口1496427人，其中男性729996人（48.78%）。总随访人年数为8081030.82，中位随访人年数为5.41[四分位数间距（）：5.29]。研究期间，炎症性肠病新发病例1217例，其中男性（624例，51.27%）多于女性（593例，48.73%）。总发病密度为15.06/10万人口年（95%：14.23，15.93）。所有新发病例中，溃疡性结肠炎1106例（90.88%），发病密度为13.69/10万人口年（95%：12.89，14.52）；克罗恩病70例（5.75%），发病密度为0.87/10万人口年（95%：0.68，1.09）；未定型结肠炎41例（3.37%），发病密度为0.51/10万人口年（95%：0.36，0.69）。溃疡性结肠炎发病年龄中位数为50.82岁（：18.77），45 - 49岁组比例最高（15.01%）。溃疡性结肠炎发病密度随年龄逐渐升高，45 - 49岁组达到较高水平（20.53/10万人口年；95%：17.63，23.78），随后略有上升。65 - 69岁组发病密度最高（25.44/10万人口年；95%：20.85，30.75），75 - 79岁组迅速下降。克罗恩病发病年龄中位数为44.34岁（：33.41），25 - 29岁组比例最高（12.86%）。由于克罗恩病新发病例数较少，年龄分布波动较大，年轻人和老年人中均有发病高峰。2011年至2020年，鄞州区炎症性肠病发病密度在2011年至2013年处于较低水平，2014年至2016年呈快速上升趋势，2016年达到峰值24.62/10万人口年（95%：21.31，28.30），2017年至2020年略有下降。
2011年至2020年鄞州区炎症性肠病发病密度处于较高水平，医疗机构和卫生部门需关注其所造成的疾病负担。
