接受一线铂类化疗的小细胞肺癌患者治疗前白蛋白与纤维蛋白原比值的预后价值
The prognostic value of pretreatment albumin-to-fibrinogen ratio in small cell lung cancer patients receiving first-line platinum-based chemotherapy.
作者信息
Li Qi, Li Li, Wang Yuchao, Xu Chunhua, Zou Jue
机构信息
Department of Respiratory Medicine, Affiliated Nanjing Brain Hospital, Nanjing Medical University, Nanjing, Jiangsu, 210029, China.
Department of Pathology, Affiliated Nanjing Brain Hospital, Nanjing Medical University, Nanjing, Jiangsu, 210029, China.
出版信息
Heliyon. 2023 Aug 22;9(9):e19225. doi: 10.1016/j.heliyon.2023.e19225. eCollection 2023 Sep.
This study examined the role of pretreatment albumin-to-fibrinogen ratio (AFR) in the prognosis of small-cell lung cancer (SCLC) patients receiving first-line platinum-based chemotherapy. A total of 131 SCLC patients were enrolled. The predictive value of the AFR for progression free survival (PFS) and overall survival (OS) were evaluated by receiver operating characteristic (ROC) curve analysis. The predictive factor of survival was assessed by univariate and multivariate Cox proportional regression analysis. The correlation between OS, PFS and AFR was determined by the log-rank test using the Kaplan-Meier method. AFR was an effective predictor of OS in SCLC patients with a cut-off value of 7.78. AFR was independent risk factors for OS and PFS. Kaplan Meier analysis showed that PFS and OS in patients with high AFR levels were significantly higher than those with low AFR levels. These results suggest that AFR could be an effective predictor of survival in patients with SCLC.
本研究探讨了治疗前白蛋白与纤维蛋白原比值（AFR）在接受一线铂类化疗的小细胞肺癌（SCLC）患者预后中的作用。共纳入131例SCLC患者。通过受试者工作特征（ROC）曲线分析评估AFR对无进展生存期（PFS）和总生存期（OS）的预测价值。通过单因素和多因素Cox比例回归分析评估生存的预测因素。采用Kaplan-Meier法通过对数秩检验确定OS、PFS与AFR之间的相关性。AFR是SCLC患者OS的有效预测指标，临界值为7.78。AFR是OS和PFS的独立危险因素。Kaplan-Meier分析表明，AFR水平高的患者的PFS和OS显著高于AFR水平低的患者。这些结果表明，AFR可能是SCLC患者生存的有效预测指标。
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