Farzan Nina, Vahabi Sepideh, Hashemi Madani Shima Sadat, Farzan Behrooz
Department of Emergency Medicine, Clinical Research Development Center, Qom University of Medical Sciences, Qom, Iran.
Department of Anesthesiology, Faculty of Medicine, Lorestan University of Medical Sciences, Khorramabad, Iran.
Ann Med Surg (Lond). 2021 Sep;69:102832. doi: 10.1016/j.amsu.2021.102832. Epub 2021 Sep 8.
Coronavirus disease 2019 (COVID-19) is associated acute respiratory distress syndrome that leads to intensive care unit admission and subsequent need of invasive ventilation. The aim of this study is to evaluate mortality rate and associated parameters among COVID 19 patients under invasive ventilation.
In this retrospective studies, COVID 19 patients referred to our center we evaluated. The data regarding demographic characteristics, comorbidities, biochemical and radiographic findings, need of invasive ventilation and mortality were collected and recorded for all the patients. Statistical analysis was performed to evaluate the risk of mortality in invasive ventilation patients relative to each risk factor or paraclinical or clinical feature.
Among patients included in the study, 63 patients underwent invasive ventilation where 53 (84%) of these died. The mortality rate among invasive ventilation was significantly associated with advanced age, p = 0.006 whereas it was not significantly associated with smoking, gender, c-reactive protein, platelet count, hypertension, lymphopenia, leukopenia, creatinine kinase, addiction, blood urea nitrogen to creatinine ratio, malignancy, cough, fever, nausea, chronic obstructive pulmonary disease and erythrocyte sedimentation rate.
The findings of our study indicate that advanced age can increase the risk of mortality in COVID 19 patients under invasive ventilation whereas, mortality among invasive ventilation patients is high, irrespective of their characteristic. Guidelines are therefore, required regarding the use of invasive ventilation among these patients.
2019冠状病毒病（COVID-19）与急性呼吸窘迫综合征相关，可导致入住重症监护病房并随后需要有创通气。本研究的目的是评估接受有创通气的COVID-19患者的死亡率及相关参数。
在这项回顾性研究中，我们评估了转诊至我们中心的COVID-19患者。收集并记录了所有患者的人口统计学特征、合并症、生化和影像学检查结果、有创通气需求及死亡率。进行统计分析以评估有创通气患者相对于各风险因素或辅助检查或临床特征的死亡风险。
在纳入研究的患者中，63例接受了有创通气，其中53例（84%）死亡。有创通气患者的死亡率与高龄显著相关（p = 0.006），而与吸烟、性别、C反应蛋白、血小板计数、高血压、淋巴细胞减少、白细胞减少、肌酸激酶、成瘾、血尿素氮与肌酐比值、恶性肿瘤、咳嗽、发热、恶心、慢性阻塞性肺疾病及红细胞沉降率无显著相关性。
我们的研究结果表明，高龄会增加接受有创通气的COVID-19患者的死亡风险，而有创通气患者的死亡率很高，与他们的特征无关。因此，需要制定关于这些患者使用有创通气的指南。
