Du Qiaolin, Sun Jian, Zhou Yanyan, Yu Yadong, Kong Weijing, Chen Chaoqun, Zhou Yifeng, Zhao Ke, Shao Changyu, Gu Xinhua
Department of Stomatology, The First Affiliated Hospital, College of Medicine, Zhejiang University Hangzhou 310003 China
Stomatology Hospital, School of Stomatology, Clinical Research Center for Oral Diseases of Zhejiang Province, Key Laboratory of Oral Biomedical Research of Zhejiang Province, Cancer Center of Zhejiang University, Zhejiang University School of Medicine Hangzhou 310006 China.
RSC Adv. 2023 Sep 1;13(37):25930-25938. doi: 10.1039/d3ra04498j. eCollection 2023 Aug 29.
The barrier membranes of guided bone regeneration (GBR) have been widely used in clinical medicine to repair bone defects. However, the unmatched mechanical strength, unsuitable degradation rates, and insufficient regeneration potential limit the application of the current barrier membranes. Here, amorphous calcium phosphate-carboxylated chitosan-polyvinyl alcohol (ACP-CCS-PVA) composite membranes are fabricated by freeze-thaw cycles, in which the ATP-stabilized ACP nanoparticles are uniformly distributed throughout the membranes. The mechanical performance and osteogenic properties are significantly improved by the ACP incorporated into the CCS-PVA system, but excess ACP would suppress cell proliferation and osteogenic differentiation. Our work highlights the pivotal role of ACP in GBR and provides insight into the need for biomaterial fabrication to balance mechanical strength and mineral content.
引导骨再生（GBR）的屏障膜已在临床医学中广泛用于修复骨缺损。然而，不匹配的机械强度、不合适的降解速率和不足的再生潜力限制了当前屏障膜的应用。在此，通过冻融循环制备了无定形磷酸钙-羧化壳聚糖-聚乙烯醇（ACP-CCS-PVA）复合膜，其中ATP稳定的ACP纳米颗粒均匀分布在整个膜中。掺入CCS-PVA体系中的ACP显著改善了机械性能和成骨特性，但过量的ACP会抑制细胞增殖和成骨分化。我们的工作突出了ACP在GBR中的关键作用，并为生物材料制造中平衡机械强度和矿物质含量的必要性提供了见解。
