Rodriguez Arley K, Tjiattas-Saleski Lindsay
Obstetrics and Gynecology, Edward Via College of Osteopathic Medicine-Carolinas, Spartanburg, USA.
Emergency Medicine, Edward Via College of Osteopathic Medicine-Carolinas, Spartanburg, USA.
Cureus. 2023 Aug 1;15(8):e42792. doi: 10.7759/cureus.42792. eCollection 2023 Aug.
Cytomegalovirus (CMV) is the most common congenital infection worldwide and in the United States. The majority of healthy adults who acquire CMV infections have few symptoms and no long-term consequences, though this is not the case for certain groups, including neonates infected in utero. This infection can lead to permanent sequelae, including death. Despite this, congenital cytomegalovirus (cCMV) is not well known among women of childbearing age. Women are more informed about neural tube defects, fetal alcohol syndrome, Down syndrome, and toxoplasmosis than they are about cCMV, although these pose less threat to the newborn. This is a case of a newborn presenting with petechiae, thrombocytopenia, and direct hyperbilirubinemia due to cCMV infection. The initial diagnosis was congenital sepsis, not cCMV. This case report highlights the importance of including a TORCH (toxoplasmosis, others, such as syphilis, rubella, CMV, and herpes) panel when considering abnormal neonatal findings. Diagnosing cCMV is critical, especially because untreated infection can cause permanent sequelae, including death.
巨细胞病毒(CMV)是全球及美国最常见的先天性感染源。大多数感染CMV的健康成年人几乎没有症状,也不会产生长期后果,但对于某些群体,包括子宫内感染的新生儿,情况并非如此。这种感染可导致永久性后遗症,包括死亡。尽管如此,先天性巨细胞病毒(cCMV)在育龄妇女中并不广为人知。与cCMV相比,女性对神经管缺陷、胎儿酒精综合征、唐氏综合征和弓形虫病更为了解,尽管这些对新生儿的威胁较小。这是一例因cCMV感染而出现瘀点、血小板减少和直接胆红素血症的新生儿病例。最初的诊断是先天性败血症,而非cCMV。本病例报告强调了在考虑新生儿异常表现时进行TORCH(弓形虫病、其他疾病,如梅毒、风疹、CMV和疱疹)检查的重要性。诊断cCMV至关重要,特别是因为未经治疗的感染可导致永久性后遗症,包括死亡。