Major-Smith Daniel, Heron Jon, Fraser Abigail, Lawlor Deborah A, Golding Jean, Northstone Kate
Population Health Sciences, University of Bristol, Bristol, BS8 2BN, UK.
MRC Integrative Epidemiology Unit, University of Bristol, Bristol, UK.
Wellcome Open Res. 2023 Sep 6;7:283. doi: 10.12688/wellcomeopenres.18564.1. eCollection 2022.
The Avon Longitudinal Study of Parents and Children (ALSPAC) is a prospective birth cohort, based in and around Bristol, UK, established to explore genetic and environmental factors impacting health and development. 14,541 pregnancies were initially recruited from 20,248 eligible pregnancies. As the G1 (Generation-1) offspring turned 7 years of age, children from eligible pregnancies who had not been enrolled into the study were invited to take part. The enrolment status of these additional G1 offspring (n=913) has been well-documented. Here we provide an updated description of the ALSPAC G0 (Generation-0) mothers study cohort (which includes newly enrolled mothers), their associated pregnancies and the data file that defines this cohort. At the time of writing there are 14,833 unique mothers enrolled in ALSPAC, with 15,447 associated pregnancies enrolled. The update to the file also includes new variables to assist researchers when using mothers' data whilst accounting for non-independence between data related to multiple pregnancies (i.e., women with more than one pregnancy in the study).
雅芳亲子纵向研究（ALSPAC）是一项前瞻性出生队列研究，位于英国布里斯托尔及其周边地区，旨在探索影响健康与发育的遗传和环境因素。最初从20248例符合条件的孕妇中招募了14541例。当第一代（G1）后代年满7岁时，邀请符合条件但尚未纳入研究的孕妇所生子女参与研究。这些额外的第一代后代（n = 913）的入组情况已有详细记录。在此，我们提供了关于ALSPAC零代（G0）母亲研究队列（包括新入组的母亲）、其相关妊娠情况以及定义该队列的数据文件的最新描述。在撰写本文时，共有14833名不同的母亲入组了ALSPAC，相关妊娠数为15447例。该文件的更新还包括新变量，以帮助研究人员在使用母亲的数据时，考虑到与多次妊娠相关的数据之间的非独立性（即研究中怀孕超过一次的女性）。
