Bales C W, Steinman L C, Freeland-Graves J H, Stone J M, Young R K
Am J Clin Nutr. 1986 Nov;44(5):664-9. doi: 10.1093/ajcn/44.5.664.
Plasma uptake of a 25 mg oral dose of zinc was measured at 0, 1, 2, 3, and 4 h postdose in 16 elderly (mean age = 7.25 yr) and 12 young (mean age = 24.0 yr) subjects selected from a group of 62 healthy nonsmokers. Elderly and young subjects were divided into two groups based upon low or high detection thresholds for solutions of sodium chloride and sucrose. Mean fasting concentrations of plasma zinc were almost identical for the two age groups. Plasma response to a zinc dose was lower (p less than 0.05) in the elderly compared to that in the young, as indicated by plasma zinc levels at hours 2 and 3 postdose and by total area under the response curve. Moderate but significant age-associated increases in detection thresholds for both sodium chloride and sucrose were found; taste thresholds were not correlated to plasma uptake of the zinc dose in either age group.
在62名健康不吸烟者中选取了16名老年人（平均年龄 = 72.5岁）和12名年轻人（平均年龄 = 24.0岁），在口服25毫克锌剂量后的0、1、2、3和4小时测量血浆锌摄取量。根据对氯化钠和蔗糖溶液的低或高检测阈值，将老年人和年轻人分为两组。两个年龄组的血浆锌空腹平均浓度几乎相同。如给药后2小时和3小时的血浆锌水平以及反应曲线下的总面积所示，老年人对锌剂量的血浆反应低于年轻人（p小于0.05）。发现氯化钠和蔗糖的检测阈值均有适度但显著的年龄相关增加；味觉阈值与两个年龄组中锌剂量的血浆摄取均无相关性。
