Morgan P N, Costa F, Donangelo C M, King J C
Department of Nutritional Sciences, University of California, Berkeley 94720.
Biol Trace Elem Res. 1994 Aug;42(2):129-42. doi: 10.1007/BF02785384.
The aim of this study was to determine whether the postprandial decline in plasma zinc concentration is altered by aging. Eleven women, between the ages of 65 and 82 yr, participated in two separate experimental protocols: a high carbohydrate breakfast trial and a fasting trial. Plasma zinc concentrations were measured from blood samples obtained at 8:00 AM (baseline fasting) and at 30-min intervals until 1:00 PM during each trial. Following the breakfast meal, plasma zinc concentrations declined 14% from 75 +/- 1 to 65 +/- 2 micrograms/dL (p < 0.05), reaching a nadir 2.7 +/- 0.2 h after the meal. This decline was significantly (p < 0.0001) greater than the 3.6% fall observed during the fasting trial. Postprandial changes in the plasma zinc concentrations were correlated with postprandial changes in serum glucose (r = -0.43, p < 0.001), serum insulin (r = -0.17, p < 0.01), and serum phosphorus (r = 0.32, p < 0.005). These data show that plasma zinc concentrations decline following food intake in elderly women in the same manner as previously described for younger adult women.
本研究的目的是确定餐后血浆锌浓度的下降是否会因衰老而改变。11名年龄在65至82岁之间的女性参与了两项独立的实验方案：高碳水化合物早餐试验和禁食试验。在每次试验期间，于上午8:00（基线空腹）采集血样，并每隔30分钟测量一次血浆锌浓度，直至下午1:00。早餐后，血浆锌浓度从75±1微克/分升降至65±2微克/分升，下降了14%（p<0.05），在餐后2.7±0.2小时达到最低点。这一下降幅度显著大于禁食试验中观察到的3.6%的下降幅度（p<0.0001）。餐后血浆锌浓度的变化与餐后血清葡萄糖（r=-0.43，p<0.001）、血清胰岛素（r=-0.17，p<0.01）和血清磷（r=0.32，p<0.005）的变化相关。这些数据表明，老年女性进食后血浆锌浓度下降的方式与先前描述的年轻成年女性相同。
