Cauley J A, Gutai J P, Sandler R B, LaPorte R E, Kuller L H, Sashin D
Am J Epidemiol. 1986 Nov;124(5):752-61. doi: 10.1093/oxfordjournals.aje.a114451.
The relationship of endogenous concentrations of estrogen, in particular estrone, to the dominant radial bone density and bone area was examined in 78 normal postmenopausal women (mean age 57 years). The women were a subset of a population participating in a clinical trial designed to determine the effects of walking on bone loss. The data reported here were collected at baseline prior to randomization. Radial cortical bone density and bone area were measured at 30 per cent of the distance between the wrist and the elbow in the dominant arm. Estrone levels obtained by extraction and column chromatography were measured by radioimmunoassay. Estrone concentrations were cross-sectionally related to both radial bone density (r = 0.39, p less than 0.001) and bone area (r = 0.39, p less than 0.001). This relationship was independent of age, number of years since onset of menopause, and degree of obesity. In multiple regression analysis, estrone levels accounted for 15 per cent of the variance in bone density and bone area in this population. These results suggest that measurement of estrone in normal postmenopausal women may assist in the identification of women who are at high risk for osteoporosis and, thus, possible candidates for estrogen replacement therapy.
在78名正常绝经后女性（平均年龄57岁）中，研究了内源性雌激素浓度，尤其是雌酮浓度，与优势侧桡骨骨密度和骨面积之间的关系。这些女性是参与一项旨在确定步行对骨质流失影响的临床试验的人群子集。此处报告的数据是在随机分组前的基线时收集的。在优势侧手臂手腕与肘部之间距离的30%处测量桡骨皮质骨密度和骨面积。通过提取和柱色谱法获得的雌酮水平采用放射免疫分析法进行测量。雌酮浓度与桡骨骨密度（r = 0.39，p < 0.001）和骨面积（r = 0.39，p < 0.001）均呈横断面相关。这种关系独立于年龄、绝经开始后的年数和肥胖程度。在多元回归分析中，雌酮水平占该人群骨密度和骨面积变异的15%。这些结果表明，测量正常绝经后女性的雌酮水平可能有助于识别骨质疏松高危女性，从而可能成为雌激素替代疗法的候选者。
