Cauley J A, Gutai J P, Kuller L H, LeDonne D, Sandler R B, Sashin D, Powell J G
Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, PA 15261.
JAMA. 1988 Dec 2;260(21):3150-5.
To examine the interactions between hormone levels and calcium with cortical bone, we have attempted to combine risk factors for the development of peak skeletal mass with factors that may be related to the maintenance of bone integrity after menopause. A total of 174 postmenopausal women participated in our study. There was little relationship found between androgen hormones and radial bone density. Estrone levels were independently related to radial bone density. Examination of the relationship of calcium intake to bone revealed a protective effect solely in women who reported high "lifetime" calcium intakes. Taking calcium and estrone together revealed an additive relationship between the two factors, in that women with high estrone and high calcium levels had significantly greater bone density than women with less calcium and/or estrone. The results suggest that a lifetime of adequate calcium intake coupled with adequate levels of serum estrogens could maximize bone density after menopause.
为了研究激素水平和钙与皮质骨之间的相互作用，我们试图将影响峰值骨量形成的风险因素与可能与绝经后骨完整性维持相关的因素结合起来。共有174名绝经后女性参与了我们的研究。雄激素与桡骨密度之间几乎没有关系。雌酮水平与桡骨密度独立相关。对钙摄入量与骨关系的研究表明，仅在报告“终生”钙摄入量高的女性中存在保护作用。同时摄入钙和雌酮显示这两个因素之间存在相加关系，即雌酮水平高且钙水平高的女性的骨密度明显高于钙和/或雌酮水平较低的女性。结果表明，终生摄入充足的钙并结合足够水平的血清雌激素可以使绝经后的骨密度最大化。
