Department of Emergency, The Affiliated Huai'an No. 1 People's Hospital of Nanjing Medical University, Huai'an, 223300, Jiangsu, China.
Department of Obstetrics and Gynecology, The Affiliated Huai'an No. 1 People's Hospital of Nanjing Medical University, Huanghe Road West,, Huai'an, 223300, Jiangsu, China.
BMC Womens Health. 2023 Sep 4;23(1):474. doi: 10.1186/s12905-023-02615-6.
This meta-analysis aimed to evaluate the effectiveness of lymphadenectomy on survival and recurrence in patients with early-stage epithelial ovarian cancer (eEOC).
Relevant studies were searched from four online databases. Hazard ratios (HRs) with 95% confidence intervals (CIs) or risk ratios (RRs) with 95% CIs were used to evaluate the effects of lymphadenectomy on overall survival (OS), progression-free survival (PFS), and recurrence rates. A subgroup analysis was performed to explore the sources of heterogeneity, followed by sensitivity and publication bias assessments.
Fourteen articles involving 22,178 subjects were included. Meta-analysis revealed that lymphadenectomy was significantly associated with improved OS (HR = 0.72; 95% CI:0.61, 0.84; P < 0.001), improved PFS (HR = 0.74; 95% CI: 0.67, 0.80; P < 0.001), and reduced recurrence rates (RR = 0.72; 95% CI: 0.60, 0.85; P < 0.001). Subgroup analysis showed that factors including area, histology, and source of the control group were significantly related to improved OS and PFS in patients with eEOC. Sensitivity analysis showed that the combined results were stable and reliable, and no significant publication bias was observed.
Patients with eEOC can benefit from lymphadenectomy, with improved survival outcomes (OS and PFS) and a lower recurrence rate.
本荟萃分析旨在评估淋巴结切除术对早期上皮性卵巢癌（eEOC）患者生存和复发的疗效。
从四个在线数据库中搜索相关研究。使用风险比（HR）和 95%置信区间（CI）或风险比（RR）和 95%CI 来评估淋巴结切除术对总生存（OS）、无进展生存（PFS）和复发率的影响。进行亚组分析以探讨异质性的来源，随后进行敏感性和发表偏倚评估。
纳入了 14 项涉及 22178 名受试者的研究。荟萃分析显示，淋巴结切除术与改善 OS（HR=0.72；95%CI：0.61，0.84；P<0.001）、改善 PFS（HR=0.74；95%CI：0.67，0.80；P<0.001）和降低复发率（RR=0.72；95%CI：0.60，0.85；P<0.001）显著相关。亚组分析显示，包括地区、组织学和对照组来源在内的因素与 eEOC 患者的 OS 和 PFS 改善显著相关。敏感性分析表明，合并结果稳定可靠，未观察到显著的发表偏倚。
eEOC 患者可从淋巴结切除术获益，生存结局（OS 和 PFS）改善，复发率降低。
