淋巴结清扫术对Ⅰ期卵巢子宫内膜样癌的影响：中美比较分析
The impact of lymph node dissection on stage I ovarian endometrioid carcinoma: A US-China Comparative Analysis.
作者信息
Sun Meige, Lin Fei, Shi Jing, Wu Xiang-Guang, Liang Yunyi, Chen Jialing, Gao Qinglei, Yao Shuzhong, Fan Jiangtao, Chen Youguo, Wang Danbo, Huang Yi, Fan Liang-Sheng, Yang Jun, Wang Wei
机构信息
Department of Obstetrics and Gynecology, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, China.
Department of Gynecological Oncology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
出版信息
iScience. 2025 Feb 10;28(3):111986. doi: 10.1016/j.isci.2025.111986. eCollection 2025 Mar 21.
This study investigated the prognostic impact of lymph node dissection (LND) in patients with stage I ovarian endometrioid carcinoma (OEC) and aimed to identify the optimal LND range for improved survival. By analyzing data from the Surveillance, Epidemiology, and End Results (SEER) database conducted in USA and NUWA database in China, we found that patients who underwent LND in the SEER cohort exhibited significantly improved long-term survival rates compared to those who did not undergo LND, while the difference was not statistically significant in the NUWA cohort. Cox regression and restricted cubic spline analyses indicated an inverted U-shaped association between the number of LNDs and hazard ratios, identifying 29-34 lymph nodes as the optimal range. This finding suggests that performing LND within this specified range may enhance survival outcomes for patients with stage I OEC.
本研究调查了淋巴结清扫术（LND）对Ⅰ期卵巢子宫内膜样癌（OEC）患者的预后影响，旨在确定可改善生存的最佳LND范围。通过分析美国监测、流行病学和最终结果（SEER）数据库以及中国女娲数据库的数据，我们发现，与未接受LND的患者相比，SEER队列中接受LND的患者长期生存率显著提高，而女娲队列中的差异无统计学意义。Cox回归和受限立方样条分析表明，LND数量与风险比之间呈倒U形关联，确定29 - 34个淋巴结为最佳范围。这一发现表明，在此特定范围内进行LND可能会改善Ⅰ期OEC患者的生存结局。
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