Geliebter A, Westreich S, Gage D, Hashim S A
Am J Physiol. 1986 Oct;251(4 Pt 2):R794-7. doi: 10.1152/ajpregu.1986.251.4.R794.
To test a less invasive method than gastric surgery for treating obesity, balloons were nonsurgically inserted in the stomachs of adult rats (mean wt = 537 g) for 8 wk. One group received balloons that were inflated with 7 ml of water, a second group had balloons inserted that were deflated, and a third group had no balloons inserted. Rats with inflated balloons ingested 27% less food (P less than 0.0005) during the 8 wk and weighted 16% less (P less than 0.05) at the end of this period than rats with deflated balloons or no balloons. Their food intake was significantly depressed through the 7th wk. The stomachs of the rats with inflated balloons were significantly heavier than the others with a thicker muscularis externa. Body composition was not significantly different among groups. A chronic intragastric balloon significantly reduced food intake and body weight.
为了测试一种比胃手术侵入性更小的治疗肥胖症的方法，将气囊非手术地插入成年大鼠（平均体重=537克）的胃中，持续8周。一组大鼠接受充入7毫升水的气囊，第二组插入未充气的气囊，第三组不插入气囊。在8周期间，充气囊的大鼠比未充气或未插气囊的大鼠摄入的食物少27%（P<0.0005），在此期间结束时体重轻16%（P<0.05）。它们的食物摄入量在第7周前显著降低。充气囊大鼠的胃明显比其他大鼠重，其肌层更厚。各组之间的身体组成没有显著差异。慢性胃内气囊显著减少了食物摄入量和体重。
