胃内气球可减少肥胖大鼠的食物摄入量和体重。
Gastric balloon reduces food intake and body weight in obese rats.
作者信息
Geliebter A, Westreich S, Hashim S A, Gage D
出版信息
Physiol Behav. 1987;39(3):399-402. doi: 10.1016/0031-9384(87)90241-1.
A less invasive method than gastric reduction surgery for treating obesity was tested by inserting balloons into the stomachs of obese rats. Male Sprague-Dawley rats were placed on a high fat diet. After 4 months, the rats weighed an average of 750 g or 23% more than rats on a chow diet. Balloons were then passed orally into the stomach, inflated with 10 ml of water, and detached from the inflating tube. Eight rats had inflated balloons; six rats had no balloons. The balloons, which could be palpated, remained inflated for 12 to 49 days with a mean of 25 days. During the period of inflation, rats with balloons consumed significantly less food (p less than 0.001) relative to rats without balloons. Gastric emptying rate was significantly slowed (p less than 0.0025) in rats with inflated balloons compared to rats with balloons that had deflated and rats with no balloons. Histology of the stomachs that held inflated balloons did not reveal pathology.
通过将气球插入肥胖大鼠的胃中，测试了一种比胃减容手术侵入性更小的治疗肥胖的方法。雄性Sprague-Dawley大鼠被给予高脂饮食。4个月后，这些大鼠的平均体重为750克，比食用普通饮食的大鼠重23%。然后将气球经口插入胃中，用10毫升水充气，然后与充气管分离。8只大鼠有充气气球；6只大鼠没有气球。这些可以触摸到的气球充气持续12至49天，平均为25天。在充气期间，有气球的大鼠相对于没有气球的大鼠摄入的食物显著减少（p<0.001）。与气球已放气的大鼠和没有气球的大鼠相比，有充气气球的大鼠胃排空率显著减慢（p<0.0025）。装有充气气球的胃的组织学检查未发现病变。
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