Exercise Hemodynamic Laboratory, School of Physical Education and Sport, University of São Paulo, São Paulo, Brazil.
Unidade de Hipertensão, Disciplina de Nefrologia, Hospital das Clínicas, HCFMUSP, Universidade de São Paulo, São Paulo, Brazil.
J Hum Hypertens. 2024 Jan;38(1):52-61. doi: 10.1038/s41371-023-00859-1. Epub 2023 Sep 5.
This study investigated the effects of dynamic resistance exercise (DRE), isometric handgrip exercise (IHE) and combined resistance exercise (DRE+IHE) on post-exercise hypotension (PEH) and its hemodynamic, autonomic, and vascular mechanisms. For that, 70 medicated hypertensives men (52 ± 8 years) were randomly allocated to perform one of the following interventions: DRE (3 sets, 8 exercises, 50% of 1RM), IHE (4 sets, 2 min, 30% of MVC), CRE (DRE+IHE) and control (CON, seated rest). Before and after the interventions, blood pressure (BP), systemic hemodynamics, cardiovascular autonomic modulation and brachial vascular parameters were evaluated. After the DRE and CRE, systolic and mean BP decreased (SBP = -7 ± 6 and -8 ± 8 mmHg; MBP -4 ± 5 and -5 ± 5 mmHg, respectively, all P < 0.05), vascular conductance increased (+ 0.47 ± 0.61 and +0.40 ± 0.47 ml.min.mmHg, respectively, both P < 0.05) and baroreflex sensitivity decreased (-0.15 ± 0.38 and -0.29 ± 0.47 ms/mmHg, respectively, both P < 0.05) in comparison to pre-exercise values. No variable presented any significant change after IHE. The responses observed after CRE were similar to DRE and significantly different from CON and IHE. In conclusion, DRE, but not IHE, elicits PEH, which happens concomitantly to skeletal muscle vasodilation and decreased baroreflex sensitivity. Moreover, adding IHE to DRE does not potentiate PEH and neither changes its mechanisms.Clinical Trial Registration: Data from this study derived from an ongoing longitudinal clinical trial approved by the Institution's Ethics Committee of Human Research (process 2.870.688) and registered at the Brazilian Clinical Trials (RBR-4fgknb) at http://www.ensaiosclinicos.gov.br .
本研究旨在探讨动态抗阻运动（DRE）、等长握力运动（IHE）和抗阻运动联合（DRE+IHE）对运动后低血压（PEH）及其血流动力学、自主神经和血管机制的影响。为此，将 70 名接受药物治疗的高血压男性（52±8 岁）随机分为以下干预组之一：DRE（3 组，8 个运动，1RM 的 50%）、IHE（4 组，2min，MVC 的 30%）、CRE（DRE+IHE）和对照组（CON，静坐休息）。在干预前后，评估血压（BP）、全身血流动力学、心血管自主神经调节和肱血管参数。DRE 和 CRE 后，收缩压和平均血压下降（SBP=-7±6 和-8±8mmHg；MBP=-4±5 和-5±5mmHg，均 P<0.05），血管传导性增加（分别增加 0.47±0.61 和 0.40±0.47ml.min.mmHg，均 P<0.05），压力反射敏感性降低（分别降低 0.15±0.38 和-0.29±0.47ms/mmHg，均 P<0.05），与运动前相比。IHE 后无变量出现显著变化。CRE 后的反应与 DRE 相似，与 CON 和 IHE 有显著差异。结论：DRE 而非 IHE 可引起 PEH，其与骨骼肌血管扩张和压力反射敏感性降低同时发生。此外，将 IHE 加入 DRE 不会增强 PEH，也不会改变其机制。临床试验注册：本研究的数据来自机构人类研究伦理委员会批准的一项正在进行的纵向临床试验（过程 2.870.688），并在巴西临床试验（RBR-4fgknb）注册，网址为 http://www.ensaiosclinicos.gov.br。
